Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2331154..2331698 Replicon chromosome
Accession NZ_CP016464
Organism Bosea sp. RAC05

Toxin (Protein)


Gene name mazF Uniprot ID A0A1B3NRD9
Locus tag BSY19_RS14495 Protein ID WP_069054780.1
Coordinates 2331154..2331477 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1B3NKU5
Locus tag BSY19_RS14500 Protein ID WP_069054781.1
Coordinates 2331474..2331698 (-) Length 75 a.a.

Genomic Context


BSY19_RS14475BSY19_RS14480BSY19_RS14485BSY19_RS14490BSY19_RS14510BSY19_RS14515BSY19_RS14520BSY19_RS14525BSY19_RS14495BSY19_RS14500BSY19_RS14505
Location: 2326833..2327888 (1056 bp)
Type: Others
Protein ID: WP_069054777.1
Location: 2327893..2328342 (450 bp)
Type: Others
Protein ID: WP_069054778.1
Location: 2328546..2329058 (513 bp)
Type: Others
Protein ID: WP_069054779.1
Location: 2329333..2330565 (1233 bp)
Type: Others
Protein ID: WP_069057115.1
Location: 2333173..2334474 (1302 bp)
Type: Others
Protein ID: WP_069057117.1
Location: 2334531..2334764 (234 bp)
Type: Others
Protein ID: WP_150129626.1
Location: 2334766..2335209 (444 bp)
Type: Others
Protein ID: WP_171905145.1
Location: 2335229..2335726 (498 bp)
Type: Others
Protein ID: WP_069054784.1
Location: 2331154..2331477 (324 bp)
Type: Toxin
Protein ID: WP_069054780.1
Location: 2331474..2331698 (225 bp)
Type: Antitoxin
Protein ID: WP_069054781.1
Location: 2331773..2332963 (1191 bp)
Type: Others
Protein ID: WP_069057116.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BSY19_RS144752326833..2327888+1056WP_069054777.1enoyl-CoA hydratase/isomerase family protein-
BSY19_RS144802327893..2328342+450WP_069054778.1hypothetical protein-
BSY19_RS144852328546..2329058+513WP_069054779.1winged helix DNA-binding protein-
BSY19_RS144902329333..2330565+1233WP_069057115.1L,D-transpeptidase family protein-
BSY19_RS144952331154..2331477-324WP_069054780.1type II toxin-antitoxin system PemK/MazF family toxinToxin
BSY19_RS145002331474..2331698-225WP_069054781.1antitoxin MazE family proteinAntitoxin
BSY19_RS145052331773..2332963-1191WP_069057116.1Na+/H+ antiporter NhaA-
BSY19_RS145102333173..2334474+1302WP_069057117.1serine hydroxymethyltransferase-
BSY19_RS145152334531..2334764+234WP_150129626.1hypothetical protein-
BSY19_RS145202334766..2335209+444WP_171905145.1hypothetical protein-
BSY19_RS145252335229..2335726+498WP_069054784.1transcriptional regulator NrdR-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-103)

Antitoxin

(6-70)


Sequences


Toxin        


Download         Length: 108 a.a.        Molecular weight: 11383.37 Da        Isoelectric Point: 10.4581

>T64671 WP_069054780.1 NZ_CP016464:c2331477-2331154 [Bosea sp. RAC05]
VTRGEIVTVAMTGDFGKPRPALVVHADPFDQTGTITVLLISGTLVDAPLIRLTVQPTPQNGLLKPSQIQIDKAMSVQRHR
VGAVIGRLDDTTMLAVTRSLALFLGIA

Download         Length: 324 bp

>T64671 NZ_CP016464:c2331477-2331154 [Bosea sp. RAC05]
GTGACGCGTGGCGAGATCGTCACCGTCGCGATGACGGGCGATTTCGGAAAGCCCCGCCCTGCCCTCGTCGTCCATGCCGA
TCCTTTCGATCAGACCGGCACCATCACCGTTCTGCTGATCTCGGGAACGCTGGTCGATGCCCCCCTGATCCGCCTGACAG
TCCAGCCGACCCCACAGAACGGACTGCTCAAACCCTCGCAGATCCAGATCGACAAGGCGATGTCGGTCCAGCGGCACAGG
GTCGGCGCCGTCATAGGAAGACTGGACGATACGACCATGCTGGCGGTGACGCGGTCACTGGCGCTGTTTCTCGGGATTGC
GTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8159.17 Da        Isoelectric Point: 4.7085

>AT64671 WP_069054781.1 NZ_CP016464:c2331698-2331474 [Bosea sp. RAC05]
MPTPVNQRVQKRRDALRAAGLRPVQIWVPDTRRPGFVEECRRQSLIVAAADADDNGLNSFLEAALADLTGEDEA

Download         Length: 225 bp

>AT64671 NZ_CP016464:c2331698-2331474 [Bosea sp. RAC05]
ATGCCCACACCCGTCAACCAGCGGGTTCAGAAGCGTCGCGATGCGCTGCGGGCCGCCGGGCTGCGGCCCGTTCAGATTTG
GGTTCCAGACACCCGCCGTCCGGGTTTTGTCGAAGAGTGCCGCCGTCAGTCGCTCATTGTCGCAGCGGCGGACGCCGACG
ATAACGGCCTGAACAGCTTTCTCGAGGCCGCTCTGGCCGATCTCACCGGCGAGGACGAGGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A1B3NRD9


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1B3NKU5

References