Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2264869..2265541 Replicon chromosome
Accession NZ_CP016464
Organism Bosea sp. RAC05

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BSY19_RS14195 Protein ID WP_069054727.1
Coordinates 2265359..2265541 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID A0A1B3NLU3
Locus tag BSY19_RS14190 Protein ID WP_069054726.1
Coordinates 2264869..2265321 (-) Length 151 a.a.

Genomic Context

BSY19_RS14175BSY19_RS14185BSY19_RS14200BSY19_RS14205BSY19_RS14210BSY19_RS14215BSY19_RS14165BSY19_RS14170BSY19_RS14180BSY19_RS14190BSY19_RS14195
Location: 2262178..2262948 (771 bp)
Type: Others
Protein ID: WP_069054724.1
Location: 2263574..2264845 (1272 bp)
Type: Others
Protein ID: WP_066720525.1
Location: 2265748..2266407 (660 bp)
Type: Others
Protein ID: WP_069054728.1
Location: 2266515..2267396 (882 bp)
Type: Others
Protein ID: WP_083247917.1
Location: 2267518..2269224 (1707 bp)
Type: Others
Protein ID: WP_069054730.1
Location: 2269307..2270377 (1071 bp)
Type: Others
Protein ID: WP_069054731.1
Location: 2259942..2260682 (741 bp)
Type: Others
Protein ID: WP_069054722.1
Location: 2260789..2262027 (1239 bp)
Type: Others
Protein ID: WP_069054723.1
Location: 2262973..2263308 (336 bp)
Type: Others
Protein ID: WP_069054725.1
Location: 2264869..2265321 (453 bp)
Type: Antitoxin
Protein ID: WP_069054726.1
Location: 2265359..2265541 (183 bp)
Type: Toxin
Protein ID: WP_069054727.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BSY19_RS141652259942..2260682-741WP_069054722.1metallophosphatase family protein-
BSY19_RS141702260789..2262027-1239WP_069054723.1aspartate kinase-
BSY19_RS141752262178..2262948+771WP_069054724.1bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG-
BSY19_RS141802262973..2263308-336WP_069054725.1hypothetical protein-
BSY19_RS141852263574..2264845+1272WP_066720525.1crotonyl-CoA carboxylase/reductase-
BSY19_RS141902264869..2265321-453WP_069054726.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
BSY19_RS141952265359..2265541-183WP_069054727.1type II toxin-antitoxin system HicA family toxinToxin
BSY19_RS142002265748..2266407+660WP_069054728.1glutathione S-transferase family protein-
BSY19_RS142052266515..2267396+882WP_083247917.1DMT family transporter-
BSY19_RS142102267518..2269224+1707WP_069054730.1acyl-CoA dehydrogenase family protein-
BSY19_RS142152269307..2270377+1071WP_069054731.1HD domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(16-141)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6813.87 Da        Isoelectric Point: 11.1367

>T64670 WP_069054727.1 NZ_CP016464:c2265541-2265359 [Bosea sp. RAC05]
MDSRDLIKELERDGWVRHSVTGSHHHFKHPSKPGKVTLPPPVKDMHPKTVKSVRRQAGLA

Download         Length: 183 bp

>T64670 NZ_CP016464:c2265541-2265359 [Bosea sp. RAC05]
ATGGATTCGCGCGACTTGATCAAGGAACTGGAGCGCGATGGATGGGTGCGTCACTCCGTGACCGGCAGCCATCACCATTT
CAAACACCCCTCGAAGCCCGGCAAGGTCACGCTGCCGCCCCCCGTCAAGGACATGCATCCAAAAACGGTGAAATCCGTGA
GACGGCAGGCGGGTCTGGCTTGA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16120.34 Da        Isoelectric Point: 5.6620

>AT64670 WP_069054726.1 NZ_CP016464:c2265321-2264869 [Bosea sp. RAC05]
MSASYFALLHLPEPGSATWGVTFPDLPGCVSSGATDEEARKKAREALAGHIAALRADGDDVPHARTLKELLGDPDIISEI
KDIFVDEHLRSGAVLENIPLDDIAPPKERINVMLDRKVLRAIDEAARARGVSRSAFIEQTAGKAALKRSA

Download         Length: 453 bp

>AT64670 NZ_CP016464:c2265321-2264869 [Bosea sp. RAC05]
ATGTCGGCCAGCTATTTTGCCCTGCTTCATTTGCCCGAGCCGGGATCGGCGACCTGGGGTGTGACCTTTCCCGATCTGCC
CGGCTGCGTTTCGTCGGGAGCCACGGATGAGGAAGCCAGAAAGAAGGCGCGAGAAGCCCTTGCCGGCCATATCGCAGCGT
TGCGCGCGGACGGGGACGACGTTCCCCACGCCCGGACCCTGAAAGAACTTCTCGGCGATCCTGACATCATCTCGGAGATC
AAGGACATCTTCGTCGATGAGCATCTGCGGAGCGGAGCGGTTCTGGAGAACATTCCGCTCGACGATATCGCCCCGCCGAA
GGAGCGCATCAACGTCATGCTGGACCGGAAGGTCCTGAGGGCCATCGACGAGGCGGCGCGCGCCCGCGGCGTGAGCCGGT
CGGCCTTCATCGAGCAGACGGCGGGCAAGGCGGCGCTGAAGCGCTCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1B3NLU3

References