Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1610680..1611338 Replicon chromosome
Accession NZ_CP016464
Organism Bosea sp. RAC05

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B3NNS2
Locus tag BSY19_RS11040 Protein ID WP_069054212.1
Coordinates 1610680..1611090 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B3NML4
Locus tag BSY19_RS11045 Protein ID WP_069054213.1
Coordinates 1611087..1611338 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSY19_RS11010 1606057..1606428 - 372 WP_069054207.1 hypothetical protein -
BSY19_RS11015 1606861..1607268 + 408 WP_069054208.1 DUF882 domain-containing protein -
BSY19_RS11020 1607288..1608031 - 744 WP_069054209.1 sulfite exporter TauE/SafE family protein -
BSY19_RS11025 1608136..1608879 + 744 WP_069054210.1 ArsR family transcriptional regulator -
BSY19_RS11030 1608839..1609687 - 849 WP_069057009.1 patatin-like phospholipase family protein -
BSY19_RS11035 1609769..1610683 - 915 WP_069054211.1 alpha/beta hydrolase -
BSY19_RS11040 1610680..1611090 - 411 WP_069054212.1 type II toxin-antitoxin system VapC family toxin Toxin
BSY19_RS11045 1611087..1611338 - 252 WP_069054213.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BSY19_RS11050 1611398..1612678 - 1281 WP_069054214.1 phosphoribosylamine--glycine ligase -
BSY19_RS11055 1612791..1614380 + 1590 WP_069054215.1 exodeoxyribonuclease VII large subunit -
BSY19_RS11060 1614393..1615235 - 843 WP_069057010.1 dienelactone hydrolase family protein -
BSY19_RS11065 1615327..1615548 + 222 WP_069054216.1 DUF2093 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-125)

Antitoxin

Antitoxin VapB-like

(2-82)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14431.59 Da        Isoelectric Point: 6.0685

>T64665 WP_069054212.1 NZ_CP016464:c1611090-1610680 [Bosea sp. RAC05]
VIVADSSAIIAIAFGEPEAVLFQRVLAETSDCHCSAVTFTECVMVLIGKRAATPLHAVEALFDDLKVRPAVLDLEQARLA
SEAFVRFGKGRHPASLNLGDCFSYALAKSLNAPLLYKGNDFSHTDIVSAAATGARP

Download         Length: 411 bp

>T64665 NZ_CP016464:c1611090-1610680 [Bosea sp. RAC05]
GTGATCGTCGCCGACAGTTCGGCCATCATCGCGATCGCTTTTGGCGAGCCGGAGGCGGTCCTTTTCCAAAGAGTGCTGGC
CGAGACGTCCGACTGTCACTGTTCTGCCGTCACCTTCACTGAATGCGTCATGGTCCTGATCGGCAAACGCGCCGCGACGC
CGCTGCACGCAGTGGAGGCCCTCTTCGACGACCTCAAGGTCCGGCCCGCAGTGCTGGATCTGGAGCAAGCCCGCCTTGCG
TCTGAGGCCTTCGTTCGCTTCGGCAAGGGCCGCCACCCGGCCAGCCTCAATCTCGGCGACTGCTTCTCCTACGCGCTCGC
CAAATCGCTGAATGCACCGCTGCTCTACAAGGGCAATGATTTCAGCCATACCGACATCGTCTCGGCTGCCGCGACCGGAG
CCCGCCCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9290.55 Da        Isoelectric Point: 4.8779

>AT64665 WP_069054213.1 NZ_CP016464:c1611338-1611087 [Bosea sp. RAC05]
VAILIKDAETDRIVRELAARTGRTIKDAVRFAAERELAQLPRGEARIDLVKLEETLARLRSYPVTDNRTADEILGYDENG
LPA

Download         Length: 252 bp

>AT64665 NZ_CP016464:c1611338-1611087 [Bosea sp. RAC05]
GTGGCGATCCTGATCAAGGATGCCGAGACGGACCGCATCGTCCGGGAACTCGCGGCGCGCACGGGGCGCACGATCAAGGA
CGCGGTGCGTTTCGCCGCGGAGCGCGAACTGGCTCAGCTCCCGCGTGGCGAAGCGCGCATCGATCTCGTCAAGCTCGAGG
AAACGTTGGCGCGTCTTCGCTCCTATCCGGTGACGGATAACCGGACAGCCGATGAGATCCTCGGCTATGATGAAAATGGA
CTGCCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B3NNS2

Antitoxin

Source ID Structure
AlphaFold DB A0A1B3NML4

References