Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-couple_hipB
Location 27267..27905 Replicon chromosome
Accession NZ_CP016464
Organism Bosea sp. RAC05

Toxin (Protein)


Gene name relE Uniprot ID A0A1B3NM74
Locus tag BSY19_RS03650 Protein ID WP_069052962.1
Coordinates 27651..27905 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1B3NNE9
Locus tag BSY19_RS03645 Protein ID WP_069052961.1
Coordinates 27267..27638 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSY19_RS03635 23213..25984 - 2772 WP_069052959.1 preprotein translocase subunit SecA -
BSY19_RS03640 26343..27179 + 837 WP_069052960.1 peptidylprolyl isomerase -
BSY19_RS03645 27267..27638 - 372 WP_069052961.1 helix-turn-helix transcriptional regulator Antitoxin
BSY19_RS03650 27651..27905 - 255 WP_069052962.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSY19_RS03655 28028..29278 + 1251 WP_069052963.1 bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ -
BSY19_RS03660 29368..30273 + 906 WP_171905080.1 EamA family transporter -
BSY19_RS03665 30287..30793 + 507 WP_069052965.1 hypothetical protein -
BSY19_RS03670 30805..31209 + 405 WP_069052966.1 8-oxo-dGTP diphosphatase MutT -
BSY19_RS03675 31217..31600 - 384 WP_069056829.1 DUF930 domain-containing protein -
BSY19_RS27425 31808..32098 + 291 WP_150129483.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

Cro/C1-type helix-turn-helix domain

(64-122)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9325.74 Da        Isoelectric Point: 10.7934

>T64663 WP_069052962.1 NZ_CP016464:c27905-27651 [Bosea sp. RAC05]
VKVAIYSRDALKTLRGLPTNVANRIRGKVEQYVADPASQANNVKALQGEKGYLRLRVGDWRVIFREDGSVVLIVRVAPRG
SAYD

Download         Length: 255 bp

>T64663 NZ_CP016464:c27905-27651 [Bosea sp. RAC05]
GTGAAGGTGGCGATCTACAGCAGGGACGCGCTGAAAACCCTGCGGGGCCTGCCGACGAATGTCGCCAATCGCATCCGCGG
CAAGGTCGAGCAGTATGTCGCCGACCCCGCCTCGCAGGCCAACAACGTCAAGGCCTTGCAGGGCGAAAAGGGCTATCTGA
GGCTCCGCGTCGGAGACTGGCGGGTGATCTTCCGCGAGGATGGCTCGGTGGTGCTGATCGTCCGCGTCGCGCCGCGCGGG
TCCGCCTATGATTGA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13618.52 Da        Isoelectric Point: 4.4979

>AT64663 WP_069052961.1 NZ_CP016464:c27638-27267 [Bosea sp. RAC05]
MKERLELTIDGEDFVALSREAYDRLVEAAEDAADSAAIARFEQRLAASEEEFIPSAMVDRILAGENLVRVWREHRGLTVS
ALAEMAGIAQPYLSQIETGKREGTLQTMKKIAGALRVKLDDLV

Download         Length: 372 bp

>AT64663 NZ_CP016464:c27638-27267 [Bosea sp. RAC05]
ATGAAGGAGCGACTGGAGCTGACGATCGACGGCGAGGACTTCGTCGCACTGTCGCGGGAGGCCTATGACCGCCTGGTCGA
GGCAGCCGAGGATGCGGCCGACTCCGCGGCCATCGCCCGCTTCGAGCAGCGTCTCGCCGCGAGTGAAGAAGAGTTCATCC
CCTCCGCTATGGTCGATCGCATTCTCGCGGGCGAGAACCTCGTGCGGGTCTGGCGCGAGCATCGCGGGCTGACCGTCAGC
GCGCTGGCGGAGATGGCGGGCATCGCCCAGCCCTATCTCTCGCAGATCGAGACGGGAAAACGCGAGGGAACGCTCCAGAC
GATGAAGAAGATCGCCGGGGCGCTGCGCGTGAAGCTCGACGATCTGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B3NM74

Antitoxin

Source ID Structure
AlphaFold DB A0A1B3NNE9

References