Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1730917..1731515 Replicon chromosome
Accession NZ_CP016456
Organism Sphingobium sp. RAC03

Toxin (Protein)


Gene name parE Uniprot ID A0A1B3MVB5
Locus tag BSY17_RS12915 Protein ID WP_069065807.1
Coordinates 1731201..1731515 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1B3MTV4
Locus tag BSY17_RS12910 Protein ID WP_069065806.1
Coordinates 1730917..1731204 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSY17_RS12895 1726637..1727572 - 936 WP_069065803.1 ribose-phosphate pyrophosphokinase -
BSY17_RS12900 1727707..1729368 + 1662 WP_069065804.1 NAD+ synthase -
BSY17_RS12905 1729500..1730828 + 1329 WP_069065805.1 glutamate--tRNA ligase -
BSY17_RS12910 1730917..1731204 + 288 WP_069065806.1 hypothetical protein Antitoxin
BSY17_RS12915 1731201..1731515 + 315 WP_069065807.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BSY17_RS12920 1731604..1732314 + 711 WP_069065808.1 hypothetical protein -
BSY17_RS12925 1732883..1733632 - 750 WP_069065809.1 alpha/beta hydrolase -
BSY17_RS12930 1733743..1734633 - 891 WP_171899238.1 hypothetical protein -
BSY17_RS12935 1734641..1735420 - 780 WP_083217121.1 uroporphyrinogen-III synthase -
BSY17_RS12940 1735324..1736250 - 927 WP_069065811.1 hydroxymethylbilane synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11818.61 Da        Isoelectric Point: 10.1781

>T64660 WP_069065807.1 NZ_CP016456:1731201-1731515 [Sphingobium sp. RAC03]
VKLAWTLEAGQDRRHIRTYIAKENPAAALTLDALFTKKARNLVNHPAIARPGRVTGTYELVVHRNYILVYDVADDLVRIL
RLLHARRQWPPIAGITDQAETPNE

Download         Length: 315 bp

>T64660 NZ_CP016456:1731201-1731515 [Sphingobium sp. RAC03]
GTGAAGCTCGCCTGGACGCTTGAGGCAGGCCAAGACCGGCGGCACATACGCACCTACATCGCCAAGGAAAATCCAGCGGC
CGCCCTGACGCTGGATGCATTGTTCACGAAGAAAGCGCGCAATCTGGTCAACCATCCCGCAATCGCACGCCCAGGCCGTG
TGACAGGGACATACGAGCTAGTGGTGCATCGCAACTATATCCTGGTTTACGATGTCGCCGACGATCTGGTGCGCATCCTG
CGCTTGCTCCATGCGCGCCGCCAGTGGCCGCCGATCGCTGGCATCACGGATCAAGCGGAAACCCCGAATGAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10678.64 Da        Isoelectric Point: 4.7146

>AT64660 WP_069065806.1 NZ_CP016456:1730917-1731204 [Sphingobium sp. RAC03]
MGESTFTFRVDDTLKSAFADAAKAHDRTGAQLIRDFMRDYVAGERRAADHDAWFREQVQVGLDSANAGRLVSDDDVEQEA
EAWRNETRARMAGRA

Download         Length: 288 bp

>AT64660 NZ_CP016456:1730917-1731204 [Sphingobium sp. RAC03]
ATGGGCGAGTCCACCTTTACCTTCCGGGTCGATGATACCCTTAAAAGCGCCTTTGCCGACGCGGCGAAGGCGCATGATCG
CACCGGAGCACAACTCATCCGCGATTTCATGCGCGACTATGTGGCGGGCGAACGCCGAGCGGCTGACCATGACGCATGGT
TCCGGGAGCAGGTGCAGGTCGGGCTGGATTCGGCCAATGCCGGACGTCTGGTCTCTGACGACGACGTCGAACAGGAAGCG
GAGGCATGGCGGAACGAGACGCGGGCTAGGATGGCTGGCAGGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B3MVB5

Antitoxin

Source ID Structure
AlphaFold DB A0A1B3MTV4

References