64659

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1586978..1587446 Replicon chromosome
Accession NZ_CP016456
Organism Sphingobium sp. RAC03

Toxin (Protein)


Gene name pasB Uniprot ID A0A1B3MVJ3
Locus tag BSY17_RS12275 Protein ID WP_069065716.1
Coordinates 1586978..1587244 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A1B3MZ08
Locus tag BSY17_RS12280 Protein ID WP_069065717.1
Coordinates 1587228..1587446 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSY17_RS12250 1583412..1583693 - 282 WP_069065711.1 hypothetical protein -
BSY17_RS12255 1583885..1585816 + 1932 WP_069065712.1 phosphomethylpyrimidine synthase ThiC -
BSY17_RS21320 1585868..1586224 + 357 WP_141249499.1 hypothetical protein -
BSY17_RS12265 1586272..1586685 - 414 WP_069065714.1 DUF2442 domain-containing protein -
BSY17_RS12270 1586682..1586930 - 249 WP_069065715.1 DUF4160 domain-containing protein -
BSY17_RS12275 1586978..1587244 - 267 WP_069065716.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSY17_RS12280 1587228..1587446 - 219 WP_069065717.1 TraY domain-containing protein Antitoxin
BSY17_RS12285 1587517..1587804 - 288 WP_069065718.1 type II toxin-antitoxin system RelE/ParE family toxin -
BSY17_RS12290 1587801..1588055 - 255 WP_069066941.1 type II toxin-antitoxin system ParD family antitoxin -
BSY17_RS12295 1588147..1588368 + 222 WP_037478964.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
BSY17_RS12300 1588375..1588782 + 408 WP_069065719.1 type II toxin-antitoxin system death-on-curing family toxin -
BSY17_RS12305 1588796..1589113 - 318 WP_037476942.1 hypothetical protein -
BSY17_RS12310 1589365..1591215 + 1851 WP_069065720.1 ABC transporter ATP-binding protein/permease -
BSY17_RS12315 1591330..1591725 - 396 WP_069065721.1 acyl-CoA thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-47)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10330.05 Da        Isoelectric Point: 10.7423

>T64659 WP_069065716.1 NZ_CP016456:c1587244-1586978 [Sphingobium sp. RAC03]
MAWTIEFLPDAVKELKKLDRSVARRIITTLEERIATLDDPRTLGSALTGDHAGYWRWRVGDYRVVAQIKDERVVIIIVRV
AHRRKVYR

Download         Length: 267 bp

>T64659 NZ_CP016456:c1587244-1586978 [Sphingobium sp. RAC03]
TTGGCCTGGACGATTGAGTTCCTGCCCGATGCGGTAAAGGAGTTGAAGAAACTCGACCGTAGCGTGGCCCGGCGGATCAT
TACGACATTGGAGGAACGGATCGCCACGCTGGACGATCCGCGTACGCTGGGCAGCGCGCTGACCGGCGACCATGCAGGCT
ATTGGCGCTGGCGGGTCGGCGATTATCGCGTGGTGGCGCAGATCAAGGATGAGCGGGTGGTGATTATCATCGTGCGCGTG
GCGCATCGGCGAAAGGTGTATCGGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8124.20 Da        Isoelectric Point: 4.4857

>AT64659 WP_069065717.1 NZ_CP016456:c1587446-1587228 [Sphingobium sp. RAC03]
MLAVRLTPELESRLDALAARTGRTKTFYAREAIEAHLDDLEDFYLAEERMKGFRAGDAIPLADVKRDLGLDD

Download         Length: 219 bp

>AT64659 NZ_CP016456:c1587446-1587228 [Sphingobium sp. RAC03]
ATGCTTGCCGTGCGCCTGACGCCTGAATTGGAGAGCCGCCTTGATGCGCTGGCAGCGCGGACGGGGCGGACCAAGACATT
TTATGCGCGCGAAGCAATCGAGGCGCATCTGGATGATCTGGAAGATTTTTATCTCGCCGAGGAACGGATGAAGGGTTTTC
GCGCGGGCGACGCCATTCCACTTGCCGATGTGAAGCGCGATCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B3MVJ3

Antitoxin

Source ID Structure
AlphaFold DB A0A1B3MZ08

References