Detailed information of TA system TA064657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 736497..737032
• Replicon: chromosome
• Accession: NZ_CP016456
• Organism: Sphingobium sp. RAC03

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BSY17_RS08065
• Protein ID: WP_171899205.1
• Coordinates: 736736..737032 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1B3MVC4
• Locus tag: BSY17_RS08060
• Protein ID: WP_069065127.1
• Coordinates: 736497..736739 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSY17_RS08035	731856..732146	-	291	WP_037475469.1	hypothetical protein	-
BSY17_RS08040	732261..733397	-	1137	WP_069065124.1	molecular chaperone DnaJ	-
BSY17_RS08045	733464..735362	-	1899	WP_037475465.1	molecular chaperone DnaK	-
BSY17_RS08050	735537..736010	+	474	WP_069065125.1	copper chaperone PCu(A)C	-
BSY17_RS08055	736007..736465	+	459	WP_069065126.1	vgr related protein	-
BSY17_RS08060	736497..736739	+	243	WP_069065127.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
BSY17_RS08065	736736..737032	+	297	WP_171899205.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BSY17_RS08070	737085..738887	-	1803	WP_069065129.1	succinate dehydrogenase flavoprotein subunit	-
BSY17_RS08075	738887..739276	-	390	WP_037476151.1	succinate dehydrogenase, hydrophobic membrane anchor protein	-
BSY17_RS08080	739276..739671	-	396	WP_037476149.1	succinate dehydrogenase, cytochrome b556 subunit	-
BSY17_RS08085	739870..741204	+	1335	WP_069065130.1	chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (3-78)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11320.80 Da
• Isoelectric Point: 6.3209

>T64657 WP_171899205.1 NZ_CP016456:736736-737032 [Sphingobium sp. RAC03]
VMRQIVLRPQAQDDIDKIWDYSAEQWDMDQADAYVGDIRAAIRFIATSPFIGTDCAHLARGLRKLNSGSHAIFYLHGNER
IDIVRILHQRADHLNYLE

Nucleotide

• Length: 297 bp

>T64657 NZ_CP016456:736736-737032 [Sphingobium sp. RAC03]
GTGATGCGTCAAATAGTCCTTCGGCCGCAAGCGCAGGATGATATCGACAAAATTTGGGATTATAGCGCCGAGCAATGGGA
CATGGATCAGGCGGACGCCTATGTTGGCGACATCCGCGCGGCCATACGATTTATTGCTACCAGCCCGTTCATAGGCACTG
ACTGCGCGCATCTGGCGCGCGGATTACGAAAATTGAATTCTGGTTCGCATGCGATCTTTTATCTGCATGGAAACGAACGC
ATTGATATCGTCCGCATCCTGCATCAGCGCGCGGATCATCTGAACTATCTGGAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8824.82 Da
• Isoelectric Point: 5.1548

>AT64657 WP_069065127.1 NZ_CP016456:736497-736739 [Sphingobium sp. RAC03]
MSSKTTSVALGDHFREFAERKVSEGRYGSTSEVIRAGLRMLESEEQKLEALRAAIQEGLDSGPGQEFDFDAFLAAKRSAR

Nucleotide

• Length: 243 bp

>AT64657 NZ_CP016456:736497-736739 [Sphingobium sp. RAC03]
ATGAGCAGCAAGACCACCTCCGTCGCCTTGGGCGACCATTTCCGCGAGTTCGCCGAACGCAAGGTGAGCGAAGGCCGCTA
CGGATCGACCAGCGAAGTGATCCGCGCGGGATTGCGGATGCTGGAGTCGGAAGAGCAGAAACTGGAAGCGCTGAGGGCGG
CGATTCAGGAAGGGCTGGATAGCGGGCCAGGGCAAGAGTTTGACTTCGATGCATTTTTGGCCGCAAAAAGATCCGCTCGG
TGA

Structures

Antitoxin

• AlphaFold DB: A0A1B3MVC4