Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-StbC |
Location | 28214..28881 | Replicon | chromosome |
Accession | NZ_CP016456 | ||
Organism | Sphingobium sp. RAC03 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A1B3MZA2 |
Locus tag | BSY17_RS04740 | Protein ID | WP_069064618.1 |
Coordinates | 28462..28881 (+) | Length | 140 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A1B3MR38 |
Locus tag | BSY17_RS04735 | Protein ID | WP_069064617.1 |
Coordinates | 28214..28462 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BSY17_RS04725 | 23883..27635 | + | 3753 | WP_069066792.1 | conjugal transfer protein TraG N-terminal domain-containing protein | - |
BSY17_RS04735 | 28214..28462 | + | 249 | WP_069064617.1 | Arc family DNA-binding protein | Antitoxin |
BSY17_RS04740 | 28462..28881 | + | 420 | WP_069064618.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
BSY17_RS04745 | 28894..29808 | + | 915 | WP_069064619.1 | HEPN domain-containing protein | - |
BSY17_RS04750 | 30368..32782 | - | 2415 | WP_069064620.1 | AAA family ATPase | - |
BSY17_RS04755 | 32779..33327 | - | 549 | WP_069064621.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 20543..50716 | 30173 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 14528.57 Da Isoelectric Point: 5.6558
>T64656 WP_069064618.1 NZ_CP016456:28462-28881 [Sphingobium sp. RAC03]
MIVLDTNVVSEAMRPSADPSVTDWLNRQPAETLFLTSVTLAELLFGIAALPEGKRKNALASTLDGLLKLFGGRILPFETK
AAQSYATLATHARAAGQGFPTPDGYIAAIAAATGFSVATRDTAPFDAAGVAVINPWTSH
MIVLDTNVVSEAMRPSADPSVTDWLNRQPAETLFLTSVTLAELLFGIAALPEGKRKNALASTLDGLLKLFGGRILPFETK
AAQSYATLATHARAAGQGFPTPDGYIAAIAAATGFSVATRDTAPFDAAGVAVINPWTSH
Download Length: 420 bp
>T64656 NZ_CP016456:28462-28881 [Sphingobium sp. RAC03]
ATGATCGTTCTGGACACAAATGTCGTTTCGGAGGCCATGAGACCGTCGGCAGATCCATCAGTCACCGACTGGCTCAATCG
GCAGCCGGCAGAAACACTTTTCCTGACGAGCGTGACCCTCGCCGAGCTACTGTTCGGGATTGCGGCGCTGCCCGAGGGCA
AGCGCAAAAACGCGCTTGCCTCCACATTGGACGGCCTTCTGAAATTGTTCGGCGGCCGCATCTTACCATTTGAGACCAAG
GCAGCGCAAAGTTACGCCACCCTTGCCACCCATGCCCGTGCAGCCGGACAAGGTTTTCCAACCCCAGACGGCTACATCGC
CGCTATCGCAGCGGCCACCGGCTTTTCCGTCGCGACCCGCGATACCGCTCCATTCGATGCCGCTGGCGTTGCTGTCATCA
ATCCTTGGACTTCGCACTGA
ATGATCGTTCTGGACACAAATGTCGTTTCGGAGGCCATGAGACCGTCGGCAGATCCATCAGTCACCGACTGGCTCAATCG
GCAGCCGGCAGAAACACTTTTCCTGACGAGCGTGACCCTCGCCGAGCTACTGTTCGGGATTGCGGCGCTGCCCGAGGGCA
AGCGCAAAAACGCGCTTGCCTCCACATTGGACGGCCTTCTGAAATTGTTCGGCGGCCGCATCTTACCATTTGAGACCAAG
GCAGCGCAAAGTTACGCCACCCTTGCCACCCATGCCCGTGCAGCCGGACAAGGTTTTCCAACCCCAGACGGCTACATCGC
CGCTATCGCAGCGGCCACCGGCTTTTCCGTCGCGACCCGCGATACCGCTCCATTCGATGCCGCTGGCGTTGCTGTCATCA
ATCCTTGGACTTCGCACTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8918.97 Da Isoelectric Point: 5.6977
>AT64656 WP_069064617.1 NZ_CP016456:28214-28462 [Sphingobium sp. RAC03]
MASVTVRNLPDEVHRAIRARAASNGRSAEAEIRDILEKAVKPSDRLHIGDALAQIGRDAGLTDDDADWLGKKREPATPLS
FD
MASVTVRNLPDEVHRAIRARAASNGRSAEAEIRDILEKAVKPSDRLHIGDALAQIGRDAGLTDDDADWLGKKREPATPLS
FD
Download Length: 249 bp
>AT64656 NZ_CP016456:28214-28462 [Sphingobium sp. RAC03]
ATGGCATCAGTGACGGTGAGAAATTTGCCTGACGAGGTGCATCGGGCTATTCGCGCGCGTGCAGCATCCAACGGACGGAG
TGCAGAAGCGGAAATCCGCGACATTCTGGAGAAGGCTGTCAAGCCATCTGACCGCCTCCACATTGGTGACGCTCTTGCCC
AGATCGGGCGGGATGCGGGCTTGACGGACGATGACGCCGATTGGCTTGGTAAAAAGCGTGAGCCTGCAACCCCCCTGAGC
TTCGATTGA
ATGGCATCAGTGACGGTGAGAAATTTGCCTGACGAGGTGCATCGGGCTATTCGCGCGCGTGCAGCATCCAACGGACGGAG
TGCAGAAGCGGAAATCCGCGACATTCTGGAGAAGGCTGTCAAGCCATCTGACCGCCTCCACATTGGTGACGCTCTTGCCC
AGATCGGGCGGGATGCGGGCTTGACGGACGATGACGCCGATTGGCTTGGTAAAAAGCGTGAGCCTGCAACCCCCCTGAGC
TTCGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1B3MZA2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1B3MR38 |