Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 28214..28881 Replicon chromosome
Accession NZ_CP016456
Organism Sphingobium sp. RAC03

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B3MZA2
Locus tag BSY17_RS04740 Protein ID WP_069064618.1
Coordinates 28462..28881 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B3MR38
Locus tag BSY17_RS04735 Protein ID WP_069064617.1
Coordinates 28214..28462 (+) Length 83 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSY17_RS04725 23883..27635 + 3753 WP_069066792.1 conjugal transfer protein TraG N-terminal domain-containing protein -
BSY17_RS04735 28214..28462 + 249 WP_069064617.1 Arc family DNA-binding protein Antitoxin
BSY17_RS04740 28462..28881 + 420 WP_069064618.1 type II toxin-antitoxin system VapC family toxin Toxin
BSY17_RS04745 28894..29808 + 915 WP_069064619.1 HEPN domain-containing protein -
BSY17_RS04750 30368..32782 - 2415 WP_069064620.1 AAA family ATPase -
BSY17_RS04755 32779..33327 - 549 WP_069064621.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 20543..50716 30173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-123)

Antitoxin

(9-41)


Sequences


Toxin        


Download         Length: 140 a.a.        Molecular weight: 14528.57 Da        Isoelectric Point: 5.6558

>T64656 WP_069064618.1 NZ_CP016456:28462-28881 [Sphingobium sp. RAC03]
MIVLDTNVVSEAMRPSADPSVTDWLNRQPAETLFLTSVTLAELLFGIAALPEGKRKNALASTLDGLLKLFGGRILPFETK
AAQSYATLATHARAAGQGFPTPDGYIAAIAAATGFSVATRDTAPFDAAGVAVINPWTSH

Download         Length: 420 bp

>T64656 NZ_CP016456:28462-28881 [Sphingobium sp. RAC03]
ATGATCGTTCTGGACACAAATGTCGTTTCGGAGGCCATGAGACCGTCGGCAGATCCATCAGTCACCGACTGGCTCAATCG
GCAGCCGGCAGAAACACTTTTCCTGACGAGCGTGACCCTCGCCGAGCTACTGTTCGGGATTGCGGCGCTGCCCGAGGGCA
AGCGCAAAAACGCGCTTGCCTCCACATTGGACGGCCTTCTGAAATTGTTCGGCGGCCGCATCTTACCATTTGAGACCAAG
GCAGCGCAAAGTTACGCCACCCTTGCCACCCATGCCCGTGCAGCCGGACAAGGTTTTCCAACCCCAGACGGCTACATCGC
CGCTATCGCAGCGGCCACCGGCTTTTCCGTCGCGACCCGCGATACCGCTCCATTCGATGCCGCTGGCGTTGCTGTCATCA
ATCCTTGGACTTCGCACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8918.97 Da        Isoelectric Point: 5.6977

>AT64656 WP_069064617.1 NZ_CP016456:28214-28462 [Sphingobium sp. RAC03]
MASVTVRNLPDEVHRAIRARAASNGRSAEAEIRDILEKAVKPSDRLHIGDALAQIGRDAGLTDDDADWLGKKREPATPLS
FD

Download         Length: 249 bp

>AT64656 NZ_CP016456:28214-28462 [Sphingobium sp. RAC03]
ATGGCATCAGTGACGGTGAGAAATTTGCCTGACGAGGTGCATCGGGCTATTCGCGCGCGTGCAGCATCCAACGGACGGAG
TGCAGAAGCGGAAATCCGCGACATTCTGGAGAAGGCTGTCAAGCCATCTGACCGCCTCCACATTGGTGACGCTCTTGCCC
AGATCGGGCGGGATGCGGGCTTGACGGACGATGACGCCGATTGGCTTGGTAAAAAGCGTGAGCCTGCAACCCCCCTGAGC
TTCGATTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1B3MZA2


Antitoxin

Source ID Structure
AlphaFold DB A0A1B3MR38

References