Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 42587..43115 Replicon plasmid pBSY17_4
Accession NZ_CP016454
Organism Sphingobium sp. RAC03

Toxin (Protein)


Gene name parE Uniprot ID A0A0J7XGW3
Locus tag BSY17_RS04230 Protein ID WP_066609359.1
Coordinates 42587..42877 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1B3MQI9
Locus tag BSY17_RS04235 Protein ID WP_066609365.1
Coordinates 42870..43115 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSY17_RS04215 37833..38699 - 867 WP_006953933.1 recombinase family protein -
BSY17_RS04220 38842..41751 - 2910 WP_048938210.1 Tn3 family transposase -
BSY17_RS04225 41917..42582 + 666 WP_066771020.1 hypothetical protein -
BSY17_RS04230 42587..42877 - 291 WP_066609359.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSY17_RS04235 42870..43115 - 246 WP_066609365.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BSY17_RS04240 43179..44228 - 1050 WP_083217029.1 MobA/MobL family protein -
BSY17_RS04245 44451..44720 + 270 WP_069064532.1 mobilization protein -
BSY17_RS04250 44720..45571 + 852 WP_066771028.1 hypothetical protein -
BSY17_RS04255 45568..45864 + 297 WP_083217030.1 hypothetical protein -
BSY17_RS04260 46293..47360 + 1068 WP_083217031.1 replication initiation protein -
BSY17_RS04265 47439..47873 + 435 WP_037531041.1 hypothetical protein -
BSY17_RS21475 47883..48059 - 177 WP_156521894.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..49737 49737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Antitoxin ParD

(7-79)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11106.66 Da        Isoelectric Point: 8.4901

>T64655 WP_066609359.1 NZ_CP016454:c42877-42587 [Sphingobium sp. RAC03]
MAEYRLSPRAQRDLDTIFDYTVAHWDLSQAMRYTDLIEAACANLAEAPQQAQGCANIRPGYRRRGVEQHVIYFRLTSYGI
AVIRILHQRMDAARHL

Download         Length: 291 bp

>T64655 NZ_CP016454:c42877-42587 [Sphingobium sp. RAC03]
ATGGCTGAATACCGGCTTAGTCCGAGAGCGCAGCGCGACCTCGACACGATATTCGACTACACCGTGGCGCATTGGGATTT
GTCCCAGGCGATGCGCTACACCGACCTCATCGAAGCCGCTTGCGCCAATCTGGCCGAAGCGCCGCAGCAGGCGCAGGGCT
GCGCCAATATCCGGCCCGGTTATCGGCGGCGGGGCGTCGAGCAGCATGTCATCTATTTTCGGCTGACCAGCTACGGCATC
GCCGTTATCCGTATCCTGCATCAGCGCATGGATGCGGCCCGCCACCTGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9250.24 Da        Isoelectric Point: 4.6657

>AT64655 WP_066609365.1 NZ_CP016454:c43115-42870 [Sphingobium sp. RAC03]
MATVRKTITLTEQQNSWIAAQIDAGSYTNDSEAIRDLIRREQERGLEIESIRQALIEGEQSGEPELFDFAAFKRRKAEQH
G

Download         Length: 246 bp

>AT64655 NZ_CP016454:c43115-42870 [Sphingobium sp. RAC03]
ATGGCGACCGTGCGCAAGACCATTACCCTAACCGAACAGCAAAATTCATGGATTGCCGCCCAGATCGACGCAGGCAGCTA
CACCAACGACAGCGAGGCGATCCGCGACCTCATCCGGCGTGAGCAGGAGCGCGGACTCGAGATCGAGAGTATTCGTCAGG
CGCTGATCGAGGGTGAGCAGAGTGGGGAGCCGGAGCTGTTCGATTTCGCTGCGTTCAAGCGGCGCAAAGCCGAGCAGCAT
GGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J7XGW3

Antitoxin

Source ID Structure
AlphaFold DB A0A1B3MQI9

References