Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 150226..151712 Replicon plasmid pBSY16_1
Accession NZ_CP016452
Organism Sinorhizobium sp. RAC02

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag BSY16_RS21865 Protein ID WP_069061994.1
Coordinates 150226..151488 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag BSY16_RS21870 Protein ID WP_083243213.1
Coordinates 151485..151712 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSY16_RS21840 145447..146196 - 750 WP_069061989.1 NYN domain-containing protein -
BSY16_RS21845 146581..147492 - 912 WP_069061990.1 EamA family transporter -
BSY16_RS21850 147576..148493 - 918 WP_069061991.1 dihydrodipicolinate synthase family protein -
BSY16_RS21855 148516..149124 - 609 WP_069061992.1 LysE/ArgO family amino acid transporter -
BSY16_RS21860 149224..150123 + 900 WP_069061993.1 LysR family transcriptional regulator ArgP -
BSY16_RS21865 150226..151488 - 1263 WP_069061994.1 type II toxin-antitoxin system HipA family toxin Toxin
BSY16_RS21870 151485..151712 - 228 WP_083243213.1 helix-turn-helix transcriptional regulator Antitoxin
BSY16_RS21875 152299..154647 + 2349 Protein_158 hypothetical protein -
BSY16_RS21880 154863..155234 - 372 WP_069061995.1 response regulator -
BSY16_RS21885 155394..156437 - 1044 WP_069061996.1 sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..2220160 2220160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-48)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45908.66 Da        Isoelectric Point: 5.5277

>T64650 WP_069061994.1 NZ_CP016452:c151488-150226 [Sinorhizobium sp. RAC02]
MTRVLDVYFRETKAGVLSRLEDSLLTFAYDSTYLLDQKSRAISFSMPLQEESFGDQVVRPFFSGLLPDEGARQRLAGALG
LSAGNAFGLLEVIGGECAGALSLYPTGTAPEPSGQSNAEILTSERLDEILSRLRTRPLLGGDEGVRLSLAGAQDKLAVIV
DDGYIALAKDGRPTTHILKPVIQALEGTVENEYFCMRLAARLKLPVPHVEIRLSGATAFLLVERYDRTKAADGIIERLHQ
EDLCQALSVPPELKYEAEGGPGTERSLGLIDQACARPVADRLQFIRMLIFHYLVGNADAHGKNYALLYGSDESDLAPIYD
VVCTAVYPRLSKRLAMKIGGRDVPDTIQLKHWKTLVPETKSSQRILVRDLAQMAERIVSEADALVAELAEDGIKHPILSA
IRKVISSRAGSLQRVTEQVP

Download         Length: 1263 bp

>T64650 NZ_CP016452:c151488-150226 [Sinorhizobium sp. RAC02]
ATGACCCGCGTATTGGACGTCTATTTTCGCGAGACCAAGGCCGGCGTACTCAGCCGGCTCGAAGACAGCCTGCTGACTTT
TGCCTATGACAGCACGTATCTCCTGGACCAAAAATCGCGGGCGATATCGTTCTCAATGCCCCTGCAAGAAGAATCATTTG
GTGATCAGGTTGTGCGCCCGTTTTTCTCCGGGCTATTGCCGGATGAGGGCGCGCGGCAACGGCTTGCTGGGGCGCTGGGC
CTTTCGGCAGGGAACGCCTTCGGACTGCTGGAAGTTATCGGGGGCGAATGTGCAGGGGCCCTGTCACTCTATCCTACAGG
CACGGCGCCCGAACCTTCAGGCCAGTCCAACGCCGAAATTCTCACCTCAGAACGTCTGGATGAAATTCTCAGCAGGCTGC
GGACCCGGCCTCTGCTTGGTGGAGATGAGGGCGTTCGTCTGTCGCTGGCCGGCGCGCAGGACAAACTGGCGGTCATTGTG
GATGACGGTTACATTGCCTTGGCAAAAGACGGCAGACCAACGACCCATATCTTGAAACCAGTCATCCAGGCGTTGGAAGG
CACGGTGGAAAACGAGTATTTTTGTATGCGCCTTGCTGCCCGCCTCAAGCTGCCAGTACCCCATGTCGAGATACGCCTTA
GTGGAGCCACTGCTTTTCTCCTAGTGGAACGCTATGATCGGACGAAGGCTGCAGATGGCATCATCGAGCGCCTGCATCAG
GAGGACCTCTGCCAGGCCCTTAGCGTACCGCCGGAGTTGAAGTATGAGGCTGAGGGCGGACCGGGAACAGAACGATCTCT
CGGGCTGATCGACCAGGCCTGCGCGAGGCCCGTCGCGGATCGGTTACAGTTCATCCGCATGCTGATCTTTCATTATCTCG
TGGGCAACGCCGATGCCCACGGCAAGAACTACGCCCTGCTTTACGGCTCCGATGAATCGGATCTGGCGCCGATCTACGAT
GTCGTTTGCACGGCCGTTTATCCCCGCTTGTCAAAGAGGCTCGCCATGAAAATTGGTGGCCGTGATGTGCCCGACACTAT
CCAGCTGAAGCATTGGAAGACATTGGTGCCCGAAACCAAATCTTCTCAGCGCATCCTGGTTCGCGATCTTGCCCAAATGG
CGGAAAGGATTGTGAGCGAAGCCGATGCCCTTGTCGCAGAGTTGGCCGAAGACGGGATCAAGCACCCTATCCTGAGTGCA
ATTCGCAAGGTCATCTCAAGTCGGGCTGGTTCGCTGCAGAGGGTCACGGAGCAGGTGCCTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8164.55 Da        Isoelectric Point: 10.9066

>AT64650 WP_083243213.1 NZ_CP016452:c151712-151485 [Sinorhizobium sp. RAC02]
MEKIKDTKSLGLLIRQERKEQGLTQEQLAGVIGVGVRFLRELEAGKESCQIGRAMQVLAGLGLVVSVGRRQGSRS

Download         Length: 228 bp

>AT64650 NZ_CP016452:c151712-151485 [Sinorhizobium sp. RAC02]
ATGGAAAAGATCAAAGATACGAAAAGCCTTGGCCTGCTGATCCGTCAGGAGCGCAAAGAGCAAGGGTTAACCCAGGAGCA
ACTCGCCGGGGTAATTGGCGTGGGCGTACGTTTTCTGCGTGAACTCGAGGCCGGCAAAGAGAGCTGCCAGATCGGCCGTG
CGATGCAAGTCCTAGCCGGTCTTGGTCTCGTCGTTTCCGTCGGCCGTCGCCAGGGTTCGCGATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References