Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PrlF(antitoxin)
Location 2150884..2151448 Replicon chromosome
Accession NZ_CP016448
Organism Methyloversatilis sp. RAC08

Toxin (Protein)


Gene name mazF Uniprot ID A0A1B3LIS9
Locus tag BSY238_RS10090 Protein ID WP_069039026.1
Coordinates 2151104..2151448 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1B3LMM6
Locus tag BSY238_RS10085 Protein ID WP_069039025.1
Coordinates 2150884..2151114 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSY238_RS10070 2146131..2147936 - 1806 WP_069039022.1 cation acetate symporter -
BSY238_RS10075 2147941..2148195 - 255 WP_069039023.1 DUF4212 domain-containing protein -
BSY238_RS10080 2148429..2150171 + 1743 WP_069039024.1 potassium/proton antiporter -
BSY238_RS10085 2150884..2151114 + 231 WP_069039025.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
BSY238_RS10090 2151104..2151448 + 345 WP_069039026.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BSY238_RS10095 2151868..2153256 + 1389 WP_069039027.1 integrase family protein -
BSY238_RS10100 2153854..2154195 - 342 WP_069039028.1 hypothetical protein -
BSY238_RS18350 2154756..2155829 - 1074 WP_150123923.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-108)

Antitoxin

PrlF antitoxin

(5-47)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12159.93 Da        Isoelectric Point: 9.4942

>T64644 WP_069039026.1 NZ_CP016448:2151104-2151448 [Methyloversatilis sp. RAC08]
VSFERFTVVRVPFPFTDRNATKNRPALVLSDSAAFNTPAGHSVMAMITSQGNAPWPLDCPIADPGTAGLPAPSLVRFKLF
TLDHRLVRGELGRLSAADAVSVRGGLSRLLEGSE

Download         Length: 345 bp

>T64644 NZ_CP016448:2151104-2151448 [Methyloversatilis sp. RAC08]
GTGAGCTTTGAGCGCTTCACGGTGGTGCGCGTGCCGTTTCCTTTCACCGACCGCAACGCCACCAAAAACCGCCCGGCGCT
CGTGCTGTCCGACTCCGCCGCATTCAACACCCCGGCCGGTCACTCGGTTATGGCGATGATCACGTCGCAGGGCAACGCAC
CGTGGCCGCTCGACTGCCCGATTGCCGACCCGGGCACTGCTGGCCTGCCCGCACCGTCGCTGGTGCGCTTCAAACTGTTT
ACGCTCGATCATCGACTTGTGCGCGGCGAACTTGGCAGGCTGTCCGCCGCCGATGCGGTATCTGTGCGCGGCGGTCTGAG
CCGCCTGCTGGAAGGGTCGGAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8300.35 Da        Isoelectric Point: 4.5183

>AT64644 WP_069039025.1 NZ_CP016448:2150884-2151114 [Methyloversatilis sp. RAC08]
MFAVAKITAKGQTTIPQDVRTALHVAPGDLIAWEVRADGTATVRRVQALDLEYLRAVEGTLSEWAGSADEEAYREL

Download         Length: 231 bp

>AT64644 NZ_CP016448:2150884-2151114 [Methyloversatilis sp. RAC08]
ATGTTTGCTGTCGCCAAAATTACCGCCAAGGGTCAAACCACCATTCCGCAGGACGTACGCACTGCGCTGCATGTTGCGCC
GGGCGATCTGATCGCCTGGGAAGTCCGTGCCGACGGCACGGCTACGGTGCGCCGTGTGCAGGCGCTCGATCTGGAGTACC
TGCGCGCGGTCGAAGGCACGCTTTCGGAGTGGGCGGGCAGCGCCGACGAGGAAGCCTACCGTGAGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B3LIS9

Antitoxin

Source ID Structure
AlphaFold DB A0A1B3LMM6

References