Detailed information of TA system TA064641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 3104708..3105349
• Replicon: chromosome
• Accession: NZ_CP016443
• Organism: Burkholderia stabilis strain ATCC BAA-67

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BBJ41_RS31760
• Protein ID: WP_083282035.1
• Coordinates: 3105011..3105349 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1J9PWC2
• Locus tag: BBJ41_RS31755
• Protein ID: WP_039344756.1
• Coordinates: 3104708..3105007 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBJ41_RS31740	3100618..3102225	-	1608	WP_122171969.1	OPT/YSL family transporter	-
BBJ41_RS31745	3102306..3103046	-	741	WP_069750097.1	IclR family transcriptional regulator	-
BBJ41_RS31750	3103376..3104659	+	1284	WP_069750098.1	DUF445 domain-containing protein	-
BBJ41_RS31755	3104708..3105007	-	300	WP_039344756.1	putative addiction module antidote protein	Antitoxin
BBJ41_RS31760	3105011..3105349	-	339	WP_083282035.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BBJ41_RS31765	3105712..3107352	+	1641	WP_069750100.1	acetolactate synthase large subunit	-
BBJ41_RS31770	3107382..3108815	+	1434	WP_069750101.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (16-109)

Antitoxin

• Uncharacterized protein HI1420 (6-93)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12553.44 Da
• Isoelectric Point: 8.9480

>T64641 WP_083282035.1 NZ_CP016443:c3105349-3105011 [Burkholderia stabilis]
MVDTPLSMTYSAPTFSIRTTDVFDAWFAALPDRIAKRRIQARIDRLSMGNPGDWKSAGAPVVEMRIDHGPGYRVYYVRRG
TIWVILLCGGDKSTQQADIRAAHAMLGHLDME

Nucleotide

• Length: 339 bp

>T64641 NZ_CP016443:c3105349-3105011 [Burkholderia stabilis]
ATGGTTGACACACCGCTATCGATGACATACAGTGCTCCAACATTCAGCATCCGAACCACCGACGTGTTCGACGCATGGTT
CGCCGCGCTGCCCGATCGCATCGCGAAGCGTCGTATCCAGGCGCGCATCGACCGTCTGTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCGCGCCGGTCGTCGAGATGCGGATCGACCACGGCCCCGGCTATCGCGTCTATTACGTGCGGCGCGGC
ACGATCTGGGTGATCCTGCTCTGCGGCGGCGACAAGTCCACGCAGCAAGCTGACATACGCGCCGCGCACGCGATGCTCGG
GCATCTCGATATGGAGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10649.01 Da
• Isoelectric Point: 6.3217

>AT64641 WP_039344756.1 NZ_CP016443:c3105007-3104708 [Burkholderia stabilis]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Nucleotide

• Length: 300 bp

>AT64641 NZ_CP016443:c3105007-3104708 [Burkholderia stabilis]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGACCACCTGAAGACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCGGCCTTCATCGCGCACGCGCTCGGCGTGATCGCACGCGCACGCGGCATGTCGC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCTCGAAAGCGCACGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A1J9PWC2