Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 2127096..2127615 Replicon chromosome
Accession NZ_CP016443
Organism Burkholderia stabilis strain ATCC BAA-67

Toxin (Protein)


Gene name stbE Uniprot ID A0A1D7ZMT9
Locus tag BBJ41_RS27320 Protein ID WP_069749329.1
Coordinates 2127096..2127377 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A108LKY6
Locus tag BBJ41_RS27325 Protein ID WP_048023838.1
Coordinates 2127367..2127615 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBJ41_RS27300 2122765..2123463 - 699 WP_069749325.1 MgtC/SapB family protein -
BBJ41_RS27305 2123579..2124688 + 1110 WP_069749326.1 AGE family epimerase/isomerase -
BBJ41_RS27310 2124661..2126280 - 1620 WP_069749327.1 Tar ligand binding domain-containing protein -
BBJ41_RS27315 2126585..2127028 + 444 WP_069749328.1 PaaI family thioesterase -
BBJ41_RS27320 2127096..2127377 - 282 WP_069749329.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BBJ41_RS27325 2127367..2127615 - 249 WP_048023838.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BBJ41_RS27330 2127734..2128786 - 1053 WP_069749330.1 CoA transferase -
BBJ41_RS27335 2129048..2129956 - 909 WP_069749331.1 hypothetical protein -
BBJ41_RS39675 2130121..2130570 - 450 WP_083281991.1 helix-turn-helix transcriptional regulator -
BBJ41_RS27345 2131183..2132373 - 1191 WP_069749333.1 2-methylaconitate cis-trans isomerase PrpF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10963.94 Da        Isoelectric Point: 10.7874

>T64639 WP_069749329.1 NZ_CP016443:c2127377-2127096 [Burkholderia stabilis]
MTFELAFLEPALKEWKKLDRTVRDQFKARLAERLEKPRIPSAKLHGHPDRYKIKLRSVGYRLVYEVRDAEVVVLVVAVGR
RERDAVYLAAMKR

Download         Length: 282 bp

>T64639 NZ_CP016443:c2127377-2127096 [Burkholderia stabilis]
ATGACCTTTGAGCTTGCGTTTCTCGAACCTGCGTTGAAGGAATGGAAGAAGCTCGATCGCACCGTTCGCGATCAGTTCAA
GGCCAGACTTGCCGAGCGGCTCGAGAAGCCTCGCATTCCTTCGGCCAAGCTGCACGGCCATCCGGATCGCTACAAGATCA
AGCTGCGCAGCGTCGGCTATCGTCTCGTGTACGAAGTACGCGATGCGGAAGTCGTCGTGCTGGTGGTCGCTGTCGGGCGG
CGCGAGCGCGACGCCGTTTATCTTGCTGCCATGAAACGCTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8963.31 Da        Isoelectric Point: 5.0636

>AT64639 WP_048023838.1 NZ_CP016443:c2127615-2127367 [Burkholderia stabilis]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADSRAKEKVVKVKLN
DL

Download         Length: 249 bp

>AT64639 NZ_CP016443:c2127615-2127367 [Burkholderia stabilis]
ATGCCTCACACCATTCTGGCCAGCGTGACGGCTAGCGTCTCGGAGTTGAAGCGGAACCCGATGGGGACCGTGGCGGCCGG
CGAGGGTTTCCCGGTCGCGATTCTGAATCACAACGAACCCGCGTTTTACTGCATCCCGGCGAAGACATGGGAAGCGATGG
TCGAACGTCTCGAAGATATCGAAGACAACGCACTGGCCGATTCGCGCGCCAAGGAGAAAGTCGTCAAGGTCAAGCTGAAT
GACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7ZMT9

Antitoxin

Source ID Structure
AlphaFold DB A0A108LKY6

References