Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1957350..1957915 Replicon chromosome
Accession NZ_CP016443
Organism Burkholderia stabilis strain ATCC BAA-67

Toxin (Protein)


Gene name vapC Uniprot ID A0A1D7ZMJ9
Locus tag BBJ41_RS26575 Protein ID WP_069749197.1
Coordinates 1957544..1957915 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D7ZR01
Locus tag BBJ41_RS26570 Protein ID WP_069750386.1
Coordinates 1957350..1957547 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBJ41_RS26550 1953118..1953600 + 483 WP_069749193.1 Lrp/AsnC family transcriptional regulator -
BBJ41_RS26555 1953685..1955238 - 1554 WP_069749194.1 galactarate dehydratase -
BBJ41_RS26560 1955469..1956383 + 915 WP_069749195.1 5-dehydro-4-deoxyglucarate dehydratase -
BBJ41_RS26565 1956536..1957087 - 552 WP_069749196.1 hypothetical protein -
BBJ41_RS26570 1957350..1957547 + 198 WP_069750386.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BBJ41_RS26575 1957544..1957915 + 372 WP_069749197.1 type II toxin-antitoxin system VapC family toxin Toxin
BBJ41_RS26580 1958060..1959637 - 1578 WP_069749198.1 aldehyde dehydrogenase (NADP(+)) -
BBJ41_RS26585 1959918..1961276 + 1359 WP_167362236.1 MFS transporter -
BBJ41_RS26590 1961337..1962062 - 726 WP_069749200.1 site-2 protease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13426.56 Da        Isoelectric Point: 5.8921

>T64638 WP_069749197.1 NZ_CP016443:1957544-1957915 [Burkholderia stabilis]
MILVDTSVWIDHLRAGDATLATLLEAERVLIHPFVVGELALGSLRDREMVLDALRDLPAAAPATDDEVQRMIDIVPLHGL
GIGYVDAHLLASVRLTSGSKLWTRDRRLLAAAERLQLAAHPAH

Download         Length: 372 bp

>T64638 NZ_CP016443:1957544-1957915 [Burkholderia stabilis]
ATGATTCTGGTCGACACCTCCGTCTGGATCGATCACCTGCGGGCCGGCGACGCAACACTCGCCACATTGCTGGAAGCCGA
ACGGGTATTGATCCATCCGTTCGTCGTCGGCGAACTTGCACTCGGCAGCCTGCGTGATCGCGAGATGGTGCTGGACGCGC
TACGCGACCTACCCGCCGCTGCCCCGGCAACCGATGATGAAGTTCAACGCATGATCGACATCGTGCCGCTTCACGGACTC
GGCATTGGTTACGTCGATGCGCACCTGCTCGCATCGGTCCGGCTGACCAGCGGCAGCAAGCTGTGGACACGCGACCGTCG
CCTGCTGGCCGCAGCCGAACGCCTGCAACTCGCCGCCCACCCCGCTCACTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7068.13 Da        Isoelectric Point: 10.6826

>AT64638 WP_069750386.1 NZ_CP016443:1957350-1957547 [Burkholderia stabilis]
MRTTLSLDDALLAKAQQLTGVTEKSALVREALRALIARESARRLARLGGTEPDLESIPRRPSEPA

Download         Length: 198 bp

>AT64638 NZ_CP016443:1957350-1957547 [Burkholderia stabilis]
ATGCGCACCACCTTGTCGCTGGACGACGCCCTGCTCGCCAAAGCGCAGCAGTTGACTGGCGTCACCGAGAAGTCGGCGCT
CGTCAGAGAAGCGCTGCGCGCGCTGATTGCCCGCGAAAGCGCACGACGGCTGGCGCGTCTCGGCGGCACCGAGCCCGATC
TCGAATCCATCCCTCGCCGCCCGTCGGAGCCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7ZMJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7ZR01

References