Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 1479590..1480808 | Replicon | chromosome |
| Accession | NZ_CP016443 | ||
| Organism | Burkholderia stabilis strain ATCC BAA-67 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A1D7ZLK0 |
| Locus tag | BBJ41_RS24570 | Protein ID | WP_069748859.1 |
| Coordinates | 1480227..1480808 (+) | Length | 194 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A1D7ZLK5 |
| Locus tag | BBJ41_RS24565 | Protein ID | WP_069748858.1 |
| Coordinates | 1479590..1480147 (+) | Length | 186 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BBJ41_RS24545 | 1475451..1476182 | - | 732 | WP_069748854.1 | ribonuclease T2 | - |
| BBJ41_RS24550 | 1476432..1477010 | - | 579 | WP_069748855.1 | hypothetical protein | - |
| BBJ41_RS24555 | 1477104..1478507 | - | 1404 | WP_069748856.1 | hypothetical protein | - |
| BBJ41_RS40590 | 1478557..1478886 | - | 330 | WP_156814856.1 | hypothetical protein | - |
| BBJ41_RS24560 | 1478870..1479505 | + | 636 | WP_069748857.1 | hypothetical protein | - |
| BBJ41_RS24565 | 1479590..1480147 | + | 558 | WP_069748858.1 | helix-turn-helix domain-containing protein | Antitoxin |
| BBJ41_RS24570 | 1480227..1480808 | + | 582 | WP_069748859.1 | HD domain-containing protein | Toxin |
| BBJ41_RS24575 | 1480864..1481592 | + | 729 | WP_069748860.1 | class I SAM-dependent methyltransferase | - |
| BBJ41_RS24580 | 1481878..1483071 | + | 1194 | WP_069748861.1 | efflux RND transporter periplasmic adaptor subunit | - |
| BBJ41_RS24585 | 1483074..1485092 | + | 2019 | WP_069748862.1 | MacB family efflux pump subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 194 a.a. Molecular weight: 21300.87 Da Isoelectric Point: 5.1032
>T64637 WP_069748859.1 NZ_CP016443:1480227-1480808 [Burkholderia stabilis]
MNPDTIHARLDFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRALRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAGGHRA
MNPDTIHARLDFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRALRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAGGHRA
Download Length: 582 bp
>T64637 NZ_CP016443:1480227-1480808 [Burkholderia stabilis]
ATGAACCCCGACACGATCCACGCGCGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGACGCGCGGAAAGCACCGCCGAACACAGCTGGCGGCTGTGCCTGATGGCGCTCGTATTCGCCGACGCGT
TGCCCGGCGTCGACACGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCAATCGAGCAGGCCGCGCACCCCGACAAAAGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGTCGCTCGATCG
CGCGCTGCGCGACGAAATCGTCGCGCTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCGAAGGCGC
TCGACAAGCTGGAAACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTACGCGTTCAATCTCGACTAC
GGCCGGCGCTATACCGATGCCGCGCCGCTGTTCAGCGCGATTCGCGCCATCGTCGATGCCGATACGCAGCGCAGGATCGA
CGCGGGCGGGCACCGCGCGTAA
ATGAACCCCGACACGATCCACGCGCGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGACGCGCGGAAAGCACCGCCGAACACAGCTGGCGGCTGTGCCTGATGGCGCTCGTATTCGCCGACGCGT
TGCCCGGCGTCGACACGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCAATCGAGCAGGCCGCGCACCCCGACAAAAGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGTCGCTCGATCG
CGCGCTGCGCGACGAAATCGTCGCGCTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCGAAGGCGC
TCGACAAGCTGGAAACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTACGCGTTCAATCTCGACTAC
GGCCGGCGCTATACCGATGCCGCGCCGCTGTTCAGCGCGATTCGCGCCATCGTCGATGCCGATACGCAGCGCAGGATCGA
CGCGGGCGGGCACCGCGCGTAA
Antitoxin
Download Length: 186 a.a. Molecular weight: 20217.15 Da Isoelectric Point: 9.3872
>AT64637 WP_069748858.1 NZ_CP016443:1479590-1480147 [Burkholderia stabilis]
MPASPLHAPPLGPQLKRWRALHRIKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLIEG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLPMLLGTSLWRYATPEIVRMETALDTLGWHDRAGPPSVEFDTGANASRIVP
IRGSTCRWTRMTLSDGSAARLVETL
MPASPLHAPPLGPQLKRWRALHRIKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLIEG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLPMLLGTSLWRYATPEIVRMETALDTLGWHDRAGPPSVEFDTGANASRIVP
IRGSTCRWTRMTLSDGSAARLVETL
Download Length: 558 bp
>AT64637 NZ_CP016443:1479590-1480147 [Burkholderia stabilis]
ATGCCCGCCTCGCCGCTTCACGCCCCGCCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCACCGCATCAAGCAAAG
CCATGCGGCCGAACTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCATCCAGCAGATGTCGCCGGACG
AACGCGCGACGGCCGAGCGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCGCTCGCGCGGCTGATCGAAGGC
AGCGCAGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTCGCCAGCTCGCCGGCGCGCGCGGCCGAGTTCTC
GCAGCCCCTGCCGATGCTGCTCGGCACGTCGCTGTGGCGCTACGCGACGCCGGAAATCGTCCGCATGGAAACCGCGCTCG
ACACGCTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAATTCGACACCGGCGCAAACGCGTCGCGCATCGTGCCG
ATCCGCGGCAGCACGTGCCGGTGGACGCGGATGACGCTGTCGGATGGCTCGGCCGCGCGGCTCGTCGAAACGCTCTAG
ATGCCCGCCTCGCCGCTTCACGCCCCGCCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCACCGCATCAAGCAAAG
CCATGCGGCCGAACTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCATCCAGCAGATGTCGCCGGACG
AACGCGCGACGGCCGAGCGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCGCTCGCGCGGCTGATCGAAGGC
AGCGCAGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTCGCCAGCTCGCCGGCGCGCGCGGCCGAGTTCTC
GCAGCCCCTGCCGATGCTGCTCGGCACGTCGCTGTGGCGCTACGCGACGCCGGAAATCGTCCGCATGGAAACCGCGCTCG
ACACGCTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAATTCGACACCGGCGCAAACGCGTCGCGCATCGTGCCG
ATCCGCGGCAGCACGTGCCGGTGGACGCGGATGACGCTGTCGGATGGCTCGGCCGCGCGGCTCGTCGAAACGCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1D7ZLK0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1D7ZLK5 |