Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 1363886..1364415 Replicon chromosome
Accession NZ_CP016443
Organism Burkholderia stabilis strain ATCC BAA-67

Toxin (Protein)


Gene name relE Uniprot ID A0A1D7ZL75
Locus tag BBJ41_RS24035 Protein ID WP_069748764.1
Coordinates 1364143..1364415 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1D7ZL89
Locus tag BBJ41_RS24030 Protein ID WP_069748763.1
Coordinates 1363886..1364146 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBJ41_RS24010 1359739..1361127 + 1389 WP_069748760.1 MFS transporter -
BBJ41_RS24015 1361693..1362904 + 1212 WP_069748761.1 winged helix-turn-helix domain-containing protein -
BBJ41_RS39505 1362944..1363663 - 720 Protein_1189 GNAT family N-acetyltransferase -
BBJ41_RS24030 1363886..1364146 + 261 WP_069748763.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BBJ41_RS24035 1364143..1364415 + 273 WP_069748764.1 Txe/YoeB family addiction module toxin Toxin
BBJ41_RS24040 1364540..1365370 + 831 WP_083281954.1 substrate-binding domain-containing protein -
BBJ41_RS24045 1365388..1366011 + 624 WP_069750351.1 HAD hydrolase-like protein -
BBJ41_RS24050 1366394..1366963 + 570 WP_069748766.1 DUF4142 domain-containing protein -
BBJ41_RS24055 1367076..1367675 - 600 WP_069748767.1 GNAT family N-acetyltransferase -
BBJ41_RS24060 1367732..1368646 - 915 WP_069748768.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10667.99 Da        Isoelectric Point: 8.8832

>T64636 WP_069748764.1 NZ_CP016443:1364143-1364415 [Burkholderia stabilis]
MSVRRVLFTSDARDDYVYWQGQGQDRKTLKRINQLIRDAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQI
SIVSCRYHYE

Download         Length: 273 bp

>T64636 NZ_CP016443:1364143-1364415 [Burkholderia stabilis]
ATGAGTGTGCGCCGCGTGCTCTTTACTTCCGACGCACGGGATGACTATGTCTATTGGCAGGGGCAGGGGCAGGATCGCAA
AACACTCAAGCGCATCAACCAGCTCATTCGCGACGCCCAGCGAACGCCGTTCGAAGGCATCGGCAAACCCGAACCACTGA
AAGCCAATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGACACGAACCGCCTGGTCTACGAGGCCGACGACCTTCAGATC
AGCATCGTGTCCTGCCGCTACCACTACGAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9764.05 Da        Isoelectric Point: 6.2225

>AT64636 WP_069748763.1 NZ_CP016443:1363886-1364146 [Burkholderia stabilis]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKERK
LAEDDE

Download         Length: 261 bp

>AT64636 NZ_CP016443:1363886-1364146 [Burkholderia stabilis]
ATGCGCACGATTCATTTTTCGGATGCCCGGGGCAATCTGAAGACTGTCATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATCACACGTCGTGATGCGCCGAACGCGGTGATCATGTCGCAGGACTACTACGACAGCCTGATGGAGACGGTTCACC
TGCTGCGCTCGCCGGCCAACGTTGCCCATCTCGAGCGCTCGATCGCGCAACTGCGCAAAGGCAAGGCGAAGGAACGCAAG
CTCGCCGAGGATGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7ZL75

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7ZL89

References