Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1282332..1282987 Replicon chromosome
Accession NZ_CP016443
Organism Burkholderia stabilis strain ATCC BAA-67

Toxin (Protein)


Gene name vapC Uniprot ID A0A1D7ZKY4
Locus tag BBJ41_RS23720 Protein ID WP_069748710.1
Coordinates 1282332..1282751 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D7ZL25
Locus tag BBJ41_RS23725 Protein ID WP_069748711.1
Coordinates 1282748..1282987 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBJ41_RS23695 1277714..1278508 + 795 WP_069748707.1 AraC family transcriptional regulator -
BBJ41_RS23700 1278740..1279708 + 969 WP_069750344.1 DMT family transporter -
BBJ41_RS23705 1279909..1280454 + 546 WP_069748708.1 permease -
BBJ41_RS23710 1280550..1280684 - 135 WP_034204471.1 entericidin A/B family lipoprotein -
BBJ41_RS23715 1280919..1282214 + 1296 WP_069748709.1 aspartate carbamoyltransferase -
BBJ41_RS23720 1282332..1282751 - 420 WP_069748710.1 type II toxin-antitoxin system VapC family toxin Toxin
BBJ41_RS23725 1282748..1282987 - 240 WP_069748711.1 Arc family DNA-binding protein Antitoxin
BBJ41_RS23730 1283296..1285536 + 2241 WP_069748712.1 TonB-dependent siderophore receptor -
BBJ41_RS23735 1285540..1286295 + 756 WP_069748713.1 sel1 repeat family protein -
BBJ41_RS23740 1286292..1286975 + 684 WP_069748714.1 Fe2+-dependent dioxygenase -
BBJ41_RS23745 1287102..1287341 + 240 WP_069748715.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BBJ41_RS23750 1287338..1287733 + 396 WP_069750345.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14942.21 Da        Isoelectric Point: 5.2074

>T64635 WP_069748710.1 NZ_CP016443:c1282751-1282332 [Burkholderia stabilis]
MILVDVSVISEPLRREPSAAVVEWLDAQNVETLFLAAIGLAEMRFGIATLPEGRRREALHQNLEHRIVPLFRGRILPFDE
AAGAAYASIRARVRAAGNAIAPADCFVAATAEANGLIVATRDVAPFEAAGLRVIDPWAS

Download         Length: 420 bp

>T64635 NZ_CP016443:c1282751-1282332 [Burkholderia stabilis]
ATGATCCTTGTTGATGTAAGCGTCATTTCCGAGCCACTGCGACGTGAGCCGAGCGCGGCTGTGGTCGAGTGGCTCGATGC
ACAGAACGTCGAGACGCTGTTCCTGGCCGCGATTGGTCTCGCCGAAATGCGGTTCGGTATCGCGACGTTGCCGGAAGGGC
GAAGGCGGGAGGCGTTGCATCAGAACCTCGAGCATCGCATCGTGCCGCTGTTTCGAGGCCGGATCCTGCCGTTTGACGAG
GCGGCAGGTGCGGCGTATGCGAGCATTCGCGCGCGAGTCCGTGCCGCAGGCAATGCAATCGCTCCGGCCGACTGCTTCGT
TGCGGCAACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTTGCTCCATTCGAAGCGGCGGGGTTACGCGTGA
TCGATCCGTGGGCCTCGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8704.86 Da        Isoelectric Point: 5.7066

>AT64635 WP_069748711.1 NZ_CP016443:c1282987-1282748 [Burkholderia stabilis]
MPVMTIRNLPDEVHRALRVRAAKHGRSTEAEVRDILEQAVLSSGRLKLGTLLAEIGREAGGGDFDVERDKTSTDPMSFE

Download         Length: 240 bp

>AT64635 NZ_CP016443:c1282987-1282748 [Burkholderia stabilis]
ATGCCGGTGATGACCATCCGAAATTTGCCCGACGAAGTGCATCGCGCCCTTCGGGTTCGTGCAGCCAAGCATGGGCGCAG
CACTGAAGCCGAGGTGCGCGACATTCTTGAGCAAGCTGTTCTGTCGAGCGGCCGCCTCAAGCTGGGCACGCTACTGGCGG
AAATTGGGCGGGAGGCCGGGGGGGGCGATTTCGACGTCGAGCGTGACAAGACGTCAACTGATCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7ZKY4

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7ZL25

References