Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1077476..1079241 Replicon chromosome
Accession NZ_CP016443
Organism Burkholderia stabilis strain ATCC BAA-67

Toxin (Protein)


Gene name doc Uniprot ID A0A1D7ZKK0
Locus tag BBJ41_RS22835 Protein ID WP_069748561.1
Coordinates 1078330..1079241 (-) Length 304 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1D7ZKM4
Locus tag BBJ41_RS22830 Protein ID WP_069748560.1
Coordinates 1077476..1078333 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBJ41_RS22810 1072641..1074131 - 1491 WP_069748556.1 aldehyde dehydrogenase -
BBJ41_RS22815 1074214..1075029 - 816 WP_069748557.1 aspartate dehydrogenase -
BBJ41_RS22820 1075022..1076689 - 1668 WP_069748558.1 thiamine pyrophosphate-binding protein -
BBJ41_RS22825 1076682..1077479 - 798 WP_069748559.1 SDR family oxidoreductase -
BBJ41_RS22830 1077476..1078333 - 858 WP_069748560.1 IclR family transcriptional regulator Antitoxin
BBJ41_RS22835 1078330..1079241 - 912 WP_069748561.1 alpha/beta fold hydrolase Toxin
BBJ41_RS22840 1079260..1079787 - 528 WP_069748562.1 cupin domain-containing protein -
BBJ41_RS22845 1079817..1080587 - 771 WP_069748563.1 SDR family oxidoreductase -
BBJ41_RS22850 1080580..1081650 - 1071 WP_069748564.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BBJ41_RS22855 1081706..1082017 - 312 WP_034180372.1 hypothetical protein -
BBJ41_RS22860 1082104..1083156 + 1053 WP_069748565.1 transposase -
BBJ41_RS22865 1083170..1083487 - 318 WP_069748566.1 non-heme iron oxygenase ferredoxin subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(56-284)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 304 a.a.        Molecular weight: 31098.30 Da        Isoelectric Point: 7.3895

>T64634 WP_069748561.1 NZ_CP016443:c1079241-1078330 [Burkholderia stabilis]
MSVIDKRERDRTAAFAALLGQFPEQRCEAGAAGTIGYREAGAGEAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASR
RVLAWDAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLARAMPARIAGLLLISPAGGYGSA
PAETRESRRDARLAMLAELGPTGLAEQRSGNMVSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRT
AVAVGANDAITPPAACERIAAAAHVGMQVIPQAGHAGYVEAPAVYSALIDTFCRQCDTQRGLA

Download         Length: 912 bp

>T64634 NZ_CP016443:c1079241-1078330 [Burkholderia stabilis]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGAGGCCGGCGCGGCGGGCACGATCGGCTACCGTGAAGCTGGCGCAGGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGC
TTCCCGTCGTGCTGCTGCACGGGATCGGCTCGGGTGCCGCATCGTGGGTGCGCCAGCTCGACACGCTCGGCGCATCGCGG
CGCGTGCTCGCGTGGGATGCGCCCGGTTACGGCGTATCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCGGATTACGC
GGCGTCGCTGAACGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCG
CGGGCGGCCTGGCCCGTGCGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATTTCGCCTGCGGGCGGCTACGGCAGCGCG
CCCGCCGAAACGCGTGAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAGCTCGGCCCGACCGGGTTGGCCGAGCA
GCGCAGCGGCAATATGGTTTCCGGGTTCGCGAGCGAGGATGCACGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGC
CGGCCGGTTATGCGCAGGCCACCCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGCTTTCGCGGCCGAACG
GCCGTGGCCGTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGAT
GCAGGTGATTCCGCAAGCCGGTCACGCCGGTTACGTGGAAGCGCCGGCCGTTTATTCCGCACTGATCGACACGTTCTGCC
GTCAGTGCGACACGCAGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31586.13 Da        Isoelectric Point: 7.0670

>AT64634 WP_069748560.1 NZ_CP016443:c1078333-1077476 [Burkholderia stabilis]
MNEPLKQQDTENPKSEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPERTLNRMTSATPETVDALYEVIREDTLRGYGISNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALVADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT64634 NZ_CP016443:c1078333-1077476 [Burkholderia stabilis]
ATGAACGAACCGCTGAAACAACAAGACACCGAAAACCCGAAGTCCGAAGCGAGCTACGTGGTGCCCGGCCTAGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGTGCGCCCGAGTTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATTGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCCGTGATCGA
AAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCCTGCCCGCGCATGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAGCTGCACGCGCTGTATCCGGAACGCACGCTGAACCGCATGACGAGCGCGAC
GCCGGAGACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATACGTTGCGCGGCTACGGCATCAGCAATTCGTCGTTCG
AGCGCGGTATTTCGGTGGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGTCCGGAGATCGATGCGGCGCTGGTCGCCGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAATTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTGAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7ZKK0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7ZKM4

References