Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 186060..186706 Replicon chromosome
Accession NZ_CP016443
Organism Burkholderia stabilis strain ATCC BAA-67

Toxin (Protein)


Gene name vapC Uniprot ID A0A1D7ZIM5
Locus tag BBJ41_RS18950 Protein ID WP_069747897.1
Coordinates 186299..186706 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D7ZIM8
Locus tag BBJ41_RS18945 Protein ID WP_069747896.1
Coordinates 186060..186302 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBJ41_RS18930 182138..183112 - 975 WP_069747893.1 LysR family transcriptional regulator -
BBJ41_RS18935 183556..185061 + 1506 WP_069747894.1 amino acid permease -
BBJ41_RS18940 185114..185797 - 684 WP_069747895.1 phospholipase -
BBJ41_RS18945 186060..186302 + 243 WP_069747896.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BBJ41_RS18950 186299..186706 + 408 WP_069747897.1 type II toxin-antitoxin system VapC family toxin Toxin
BBJ41_RS39320 186856..187092 - 237 WP_083281920.1 hypothetical protein -
BBJ41_RS18955 187150..189530 + 2381 Protein_163 MCP four helix bundle domain-containing protein -
BBJ41_RS18960 189553..190281 + 729 WP_069750261.1 chemotaxis protein -
BBJ41_RS18965 190278..190850 + 573 WP_069747898.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14670.80 Da        Isoelectric Point: 5.9778

>T64631 WP_069747897.1 NZ_CP016443:186299-186706 [Burkholderia stabilis]
MKFLLDTNAVIAILKGEPVVLARLRQHEPADFGVPAIVAHELYYGAYKSQRMAANVARVEALQLEVVTFDAEDAQHAGAI
RAHLTAAGTPIGPYDALIAGQARARRLVLVTHNMREFESVPGLQVEDWLAGVNES

Download         Length: 408 bp

>T64631 NZ_CP016443:186299-186706 [Burkholderia stabilis]
ATGAAGTTTCTGCTGGATACCAATGCGGTCATCGCCATTCTCAAAGGCGAGCCGGTCGTGCTGGCCCGATTGCGGCAGCA
TGAACCGGCCGATTTCGGGGTGCCGGCAATCGTCGCGCACGAGCTCTATTACGGCGCCTACAAAAGCCAGCGAATGGCTG
CGAACGTGGCGCGTGTCGAGGCGCTTCAGTTGGAGGTCGTGACGTTCGACGCGGAAGATGCTCAGCATGCCGGCGCGATC
CGCGCGCATTTGACGGCGGCAGGAACGCCCATCGGTCCGTATGATGCGTTGATCGCGGGGCAGGCGCGTGCGCGGCGGCT
GGTGCTTGTCACGCATAACATGCGCGAATTCGAAAGCGTTCCCGGCCTTCAGGTCGAGGATTGGCTCGCAGGCGTGAACG
AAAGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8998.24 Da        Isoelectric Point: 5.0623

>AT64631 WP_069747896.1 NZ_CP016443:186060-186302 [Burkholderia stabilis]
MDIAKIFKHGGSQAVRLPKDFRFETTEVRIRRHGAAVILEPVPQDWVWLTPLIGPVDADFEAAATARQADQERPGLDVFE

Download         Length: 243 bp

>AT64631 NZ_CP016443:186060-186302 [Burkholderia stabilis]
ATGGATATTGCCAAAATCTTCAAGCATGGCGGATCGCAGGCCGTTCGGCTGCCGAAGGATTTTCGCTTCGAGACGACGGA
GGTCCGGATTCGCCGCCACGGGGCGGCCGTCATCCTCGAGCCGGTGCCGCAAGATTGGGTGTGGTTGACACCGCTGATCG
GTCCGGTCGACGCCGATTTCGAGGCTGCTGCAACCGCCCGGCAGGCCGATCAGGAGCGCCCGGGACTGGACGTGTTTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7ZIM5

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7ZIM8

References