Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 2219824..2220461 Replicon chromosome
Accession NZ_CP016442
Organism Burkholderia stabilis strain ATCC BAA-67

Toxin (Protein)


Gene name vapC Uniprot ID A0A1D7ZDB5
Locus tag BBJ41_RS10270 Protein ID WP_069746410.1
Coordinates 2220060..2220461 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1D7ZDB2
Locus tag BBJ41_RS10265 Protein ID WP_069746409.1
Coordinates 2219824..2220060 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBJ41_RS10250 2215528..2216562 + 1035 WP_069746406.1 helix-turn-helix domain-containing protein -
BBJ41_RS10255 2216627..2217727 - 1101 WP_069746407.1 ADP-heptose--LPS heptosyltransferase -
BBJ41_RS10260 2217724..2219427 - 1704 WP_069746408.1 thiamine pyrophosphate-binding protein -
BBJ41_RS10265 2219824..2220060 + 237 WP_069746409.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BBJ41_RS10270 2220060..2220461 + 402 WP_069746410.1 type II toxin-antitoxin system VapC family toxin Toxin
BBJ41_RS10275 2220529..2221917 - 1389 WP_069746411.1 L-serine ammonia-lyase -
BBJ41_RS10280 2221948..2223081 - 1134 WP_069747662.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14900.03 Da        Isoelectric Point: 5.6473

>T64630 WP_069746410.1 NZ_CP016442:2220060-2220461 [Burkholderia stabilis]
MPRYMLDTNMCIYLMKHQPEQVARRFAQCYTGDVVMSAITYAELEYGVTVCANPARERGNLAALIEDIPVAPFDAPAAQA
YGPVRAATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFASYPGVRLENWLND

Download         Length: 402 bp

>T64630 NZ_CP016442:2220060-2220461 [Burkholderia stabilis]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTACCTGATGAAGCATCAGCCGGAACAGGTCGCAAGACGATTTGC
GCAGTGCTACACGGGGGACGTCGTGATGTCGGCGATTACCTATGCCGAGCTCGAATACGGCGTGACCGTGTGCGCGAATC
CCGCCAGGGAGCGCGGCAATCTTGCCGCGCTGATCGAGGATATTCCGGTTGCGCCGTTCGACGCGCCGGCCGCGCAAGCG
TACGGCCCTGTCCGCGCAGCGACCCGCGAGCGGAAGAAGGATCATCTCGACAAACTGATCGCGGCTCATGCGGTGTCGCT
CGACGTCGTTCTCGTGACCAACAACGAGCGGGATTTTGCGAGCTACCCGGGGGTGCGGCTGGAGAACTGGCTGAACGACT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8923.02 Da        Isoelectric Point: 5.7252

>AT64630 WP_069746409.1 NZ_CP016442:2219824-2220060 [Burkholderia stabilis]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTGVLEKFAKFGPDFMAEGRGDHEQADREGL

Download         Length: 237 bp

>AT64630 NZ_CP016442:2219824-2220060 [Burkholderia stabilis]
ATGCATACCACGAGGGTATTTCGGAACGGCAACTCTCAGGCCGTACGGATTCCGGCAGACCTTGCCTACGAGCGCAGCGA
TATCGAGCTCGAAATTGAACGGATCGGCGACGAAATCCGGATTCGGCCGGCGCGACGGCCGTTGACCGGCGTGCTCGAGA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCCGAAGGGCGTGGCGACCACGAGCAGGCTGACCGCGAGGGGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7ZDB5

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7ZDB2

References