Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 794799..795475 Replicon chromosome
Accession NZ_CP016442
Organism Burkholderia stabilis strain ATCC BAA-67

Toxin (Protein)


Gene name vagD Uniprot ID A0A1D7ZA38
Locus tag BBJ41_RS03820 Protein ID WP_069745384.1
Coordinates 794799..795215 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1D7ZA06
Locus tag BBJ41_RS03825 Protein ID WP_069745385.1
Coordinates 795212..795475 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBJ41_RS03800 790583..791122 - 540 WP_069747571.1 outer membrane protein assembly factor BamE -
BBJ41_RS03805 791297..792421 - 1125 WP_069745381.1 amidohydrolase -
BBJ41_RS03810 792803..793876 + 1074 WP_069745382.1 hypothetical protein -
BBJ41_RS03815 793845..794750 + 906 WP_069745383.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
BBJ41_RS03820 794799..795215 - 417 WP_069745384.1 type II toxin-antitoxin system VapC family toxin Toxin
BBJ41_RS03825 795212..795475 - 264 WP_069745385.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BBJ41_RS03830 795702..796718 - 1017 WP_069745386.1 acetyltransferase -
BBJ41_RS03835 796718..797557 - 840 WP_069747572.1 N(5)-hydroxyornithine transformylase PvdF -
BBJ41_RS03840 797644..799905 - 2262 WP_069745387.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14578.74 Da        Isoelectric Point: 7.2439

>T64629 WP_069745384.1 NZ_CP016442:c795215-794799 [Burkholderia stabilis]
VTTLYMLDTNICSFIMRERPPVVLSQLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAVIRSDLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLLLEDWAA

Download         Length: 417 bp

>T64629 NZ_CP016442:c795215-794799 [Burkholderia stabilis]
GTGACGACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAACGGCCGCCTGTGGTGCTGTCTCAATT
GCAATCGTGCGTCAATGCGCAGCACCGGATCGTCGTATCGGCGATCACCTATGCCGAGATGCGGTTCGGCGCGGTCGGCA
GGAAGGCGTCGCCGAAGCATGCGGAACTGGTGACGGCCTTTGTCTCGCGGCTGGATGGCGTGTTGTCGTGGGATACGGCG
GCCGTCGATGCAACGGCCGTGATTCGCTCCGATCTCGCCGCGCGCGGCACACCAATCGGTGCGAACGATGCGTCGATCGC
CGGGCATGCGATCGCGGCCGGCGCGGTGCTCGTCACGAACAACGGTCGCGAATTCGGCCGTGTCGCCGGGTTGCTGCTCG
AAGACTGGGCAGCCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9691.92 Da        Isoelectric Point: 4.4819

>AT64629 WP_069745385.1 NZ_CP016442:c795475-795212 [Burkholderia stabilis]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPLADTDFLAERPAVIESGRFDLSGGDA
APTESGQ

Download         Length: 264 bp

>AT64629 NZ_CP016442:c795475-795212 [Burkholderia stabilis]
ATGCGCACCGTTTCGATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGTGTGAC
GGAACTCGAGATTCGCCGCGAGGGCGACACGCTGCTGCTGCGCCCGGTGCGCCCCACGTGGCTCTCGTTCGCGAGCGAAC
CGCTGGCCGACACCGACTTCCTCGCCGAACGCCCGGCCGTCATCGAGTCCGGCCGCTTCGACCTGTCCGGCGGCGACGCC
GCGCCGACGGAGTCCGGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7ZA38

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7ZA06

References