Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1564804..1565384 Replicon chromosome
Accession NZ_CP016433
Organism Rhizobium sp. S41

Toxin (Protein)


Gene name vapC Uniprot ID A0A098RHQ3
Locus tag BA939_RS21885 Protein ID WP_037094892.1
Coordinates 1564804..1565187 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A098RIA2
Locus tag BA939_RS21890 Protein ID WP_037094899.1
Coordinates 1565184..1565384 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA939_RS21875 1563255..1564007 + 753 WP_065653688.1 IS6 family transposase -
BA939_RS21880 1564042..1564446 + 405 Protein_1450 hypothetical protein -
BA939_RS21885 1564804..1565187 - 384 WP_037094892.1 type II toxin-antitoxin system VapC family toxin Toxin
BA939_RS21890 1565184..1565384 - 201 WP_037094899.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BA939_RS21895 1565540..1566586 - 1047 WP_052114357.1 ABC transporter ATP-binding protein -
BA939_RS21900 1566586..1567563 - 978 WP_037094889.1 ABC transporter ATP-binding protein -
BA939_RS21905 1567560..1568474 - 915 WP_037094887.1 ABC transporter permease -
BA939_RS21910 1568478..1569398 - 921 WP_052114356.1 ABC transporter permease -
BA939_RS21915 1569484..1570170 - 687 WP_037094877.1 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1563255..1564007 752
- flank IS/Tn - - 1569484..1570170 686


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13898.93 Da        Isoelectric Point: 6.3707

>T64628 WP_037094892.1 NZ_CP016433:c1565187-1564804 [Rhizobium sp. S41]
VILVDSSIWIDHFRHGDSELIKIIGDDQLLCHPFVVGELALGSLRDRDAVLAFLAAQREAVVATHAEVMTVIDRYSVFSM
GIGHTDAHLLTSTLLDQRSSLWTRDKRLAAAAQKVGAALYPSANIPH

Download         Length: 384 bp

>T64628 NZ_CP016433:c1565187-1564804 [Rhizobium sp. S41]
GTGATCCTTGTCGATAGCTCAATCTGGATTGATCATTTTCGACACGGCGACTCGGAGCTGATCAAAATCATCGGAGATGA
TCAGTTGCTTTGCCACCCGTTCGTTGTCGGCGAACTGGCTCTGGGTAGTCTGCGAGATCGGGATGCGGTACTAGCGTTTC
TTGCAGCTCAGCGTGAGGCAGTTGTCGCGACACATGCAGAGGTGATGACCGTTATTGACCGCTATTCGGTATTCAGCATG
GGAATCGGCCATACTGATGCCCATCTGTTGACTTCAACCCTCCTCGATCAACGATCAAGCTTGTGGACGAGGGATAAACG
CCTCGCGGCTGCGGCTCAGAAGGTTGGCGCGGCGCTTTATCCTTCCGCGAATATTCCTCACTAG

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7240.43 Da        Isoelectric Point: 10.9054

>AT64628 WP_037094899.1 NZ_CP016433:c1565384-1565184 [Rhizobium sp. S41]
MRSTISLDDKLMERAKSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPEAEVAPRRRSEVSK

Download         Length: 201 bp

>AT64628 NZ_CP016433:c1565384-1565184 [Rhizobium sp. S41]
ATGCGATCTACTATCAGTCTTGACGACAAGCTCATGGAACGTGCCAAGTCCCTCACAGGCACAAAGGAAACGGCGGCTCT
GGTGCGTCAAGCACTCGAGACTTTGGTACGAGTCGAATCCGGCAAACGGCTGATTGCTCTTGGCGGCACTATGCCCGAGG
CCGAAGTAGCGCCTCGCCGCCGGAGCGAAGTGAGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A098RHQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A098RIA2

References