Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1392411..1393006 Replicon chromosome
Accession NZ_CP016432
Organism Prosthecochloris sp. CIB 2401 strain CIB2401

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag Ptc2401_RS06645 Protein ID WP_068868243.1
Coordinates 1392411..1392716 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1B1Q2R1
Locus tag Ptc2401_RS06650 Protein ID WP_068867380.1
Coordinates 1392713..1393006 (+) Length 98 a.a.

Genomic Context

Ptc2401_RS11430Ptc2401_RS06615Ptc2401_RS06620Ptc2401_RS06625Ptc2401_RS06645Ptc2401_RS06650Ptc2401_RS06630Ptc2401_RS06635Ptc2401_RS06640Ptc2401_RS06655Ptc2401_RS06660Ptc2401_RS06665
Location: 1388830..1389189 (360 bp)
Type: Others
Protein ID: WP_114616832.1
Location: 1389186..1389389 (204 bp)
Type: Others
Protein ID: WP_068867379.1
Location: 1389770..1390075 (306 bp)
Type: Others
Protein ID: WP_068868242.1
Location: 1390072..1390365 (294 bp)
Type: Others
Protein ID: WP_068867380.1
Location: 1392411..1392716 (306 bp)
Type: Toxin
Protein ID: WP_068868243.1
Location: 1392713..1393006 (294 bp)
Type: Antitoxin
Protein ID: WP_068867380.1
Location: 1390634..1391104 (471 bp)
Type: Others
Protein ID: WP_068867381.1
Location: 1391101..1391550 (450 bp)
Type: Others
Protein ID: WP_068867382.1
Location: 1391566..1392132 (567 bp)
Type: Others
Protein ID: WP_068867383.1
Location: 1393188..1395137 (1950 bp)
Type: Others
Protein ID: WP_068867384.1
Location: 1395203..1396360 (1158 bp)
Type: Others
Protein ID: WP_068868244.1
Location: 1396477..1397682 (1206 bp)
Type: Others
Protein ID: WP_068867385.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Ptc2401_RS114301388830..1389189+360WP_114616832.1hypothetical protein-
Ptc2401_RS066151389186..1389389+204WP_068867379.1hypothetical protein-
Ptc2401_RS066201389770..1390075+306WP_068868242.1type II toxin-antitoxin system RelE/ParE family toxin-
Ptc2401_RS066251390072..1390365+294WP_068867380.1putative addiction module antidote protein-
Ptc2401_RS066301390634..1391104-471WP_068867381.1hypothetical protein-
Ptc2401_RS066351391101..1391550-450WP_068867382.1helix-turn-helix domain-containing protein-
Ptc2401_RS066401391566..1392132-567WP_068867383.1hypothetical protein-
Ptc2401_RS066451392411..1392716+306WP_068868243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
Ptc2401_RS066501392713..1393006+294WP_068867380.1putative addiction module antidote proteinAntitoxin
Ptc2401_RS066551393188..1395137-1950WP_068867384.1glutamine--fructose-6-phosphate transaminase (isomerizing)-
Ptc2401_RS066601395203..1396360-1158WP_068868244.1UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)-
Ptc2401_RS066651396477..1397682-1206WP_068867385.1UDP-N-acetyl-D-mannosamine dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--1349007..139882149814


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(6-97)

Antitoxin

Uncharacterized protein HI1420

(6-91)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11473.15 Da        Isoelectric Point: 9.8054

>T64625 WP_068868243.1 NZ_CP016432:1392411-1392716 [Prosthecochloris sp. CIB 2401]
MNTFIRSSDFDTWLSAMKDQKAKARILCRIQSAIHGNFGDCEPVGEGVSEMRIHVGQGYRLYYTRTGKTVYFLLAGGNKR
TQGKDIVRAKELARELKETEL

Download         Length: 306 bp

>T64625 NZ_CP016432:1392411-1392716 [Prosthecochloris sp. CIB 2401]
ATGAACACCTTCATCCGCTCATCTGATTTCGATACTTGGCTCAGTGCCATGAAAGACCAGAAAGCAAAAGCAAGGATCCT
CTGCCGCATTCAAAGCGCCATACATGGAAACTTTGGCGATTGTGAACCGGTAGGTGAAGGGGTTTCAGAAATGCGGATTC
ACGTGGGGCAAGGATACCGGCTCTATTACACGCGAACAGGAAAAACGGTCTATTTCCTGCTTGCTGGCGGCAACAAGCGA
ACACAGGGAAAAGACATTGTCCGTGCGAAAGAATTAGCCAGAGAACTCAAGGAAACAGAACTATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10321.75 Da        Isoelectric Point: 7.1993

>AT64625 WP_068867380.1 NZ_CP016432:1392713-1393006 [Prosthecochloris sp. CIB 2401]
MKTTYATFDIAEYLDNDEVIAEYLSVAAADKNPDVFIAAIGDVAKAKGMASIAKTAGLGRESLYKALRKGARPRFDTINA
VLHAIGAKFTVTSADHS

Download         Length: 294 bp

>AT64625 NZ_CP016432:1392713-1393006 [Prosthecochloris sp. CIB 2401]
ATGAAAACGACCTACGCAACATTTGACATTGCAGAATACCTCGATAACGATGAGGTCATTGCAGAATACCTTTCTGTTGC
AGCTGCAGACAAAAACCCCGATGTGTTCATTGCTGCTATCGGCGATGTCGCCAAAGCAAAAGGAATGGCCAGCATAGCCA
AGACTGCCGGCCTCGGTCGTGAAAGCCTGTACAAAGCACTGAGAAAAGGTGCCCGGCCGCGCTTTGACACTATCAATGCC
GTCCTGCATGCCATTGGAGCAAAATTCACCGTAACGAGTGCCGATCATTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1B1Q2R1

References