Detailed information of TA system TA064623

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 560226..560694
• Replicon: chromosome
• Accession: NZ_CP016432
• Organism: Prosthecochloris sp. CIB 2401 strain CIB2401

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: Ptc2401_RS11120
• Protein ID: WP_083188109.1
• Coordinates: 560226..560486 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A5C4S0N8
• Locus tag: Ptc2401_RS02550
• Protein ID: WP_041702602.1
• Coordinates: 560470..560694 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Ptc2401_RS02525	555690..556442	+	753	WP_068866443.1	YebC/PmpR family DNA-binding transcriptional regulator	-
Ptc2401_RS02530	556446..557006	+	561	WP_068866445.1	crossover junction endodeoxyribonuclease RuvC	-
Ptc2401_RS02535	557057..557593	+	537	WP_068866447.1	CDP-alcohol phosphatidyltransferase family protein	-
Ptc2401_RS02540	557660..559060	-	1401	WP_068868178.1	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/3-hydroxyacyl-ACP dehydratase	-
Ptc2401_RS02545	559108..559911	-	804	WP_068866449.1	inositol monophosphatase	-
Ptc2401_RS11120	560226..560486	-	261	WP_083188109.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Ptc2401_RS02550	560470..560694	-	225	WP_041702602.1	ribbon-helix-helix protein, CopG family	Antitoxin
Ptc2401_RS02555	561261..562796	+	1536	WP_068866450.1	Fic family protein	-
Ptc2401_RS11125	563230..563512	-	283	Protein_495	Txe/YoeB family addiction module toxin	-
Ptc2401_RS02560	563488..563751	-	264	WP_068866452.1	hypothetical protein	-
Ptc2401_RS02565	564151..564486	-	336	Protein_497	FAD:protein FMN transferase	-
Ptc2401_RS11565	564378..565274	-	897	Protein_498	integron integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	457375..695810	238435

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-85)

Antitoxin

• Relaxosome protein TraY (8-48)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10070.71 Da
• Isoelectric Point: 10.6191

>T64623 WP_083188109.1 NZ_CP016432:c560486-560226 [Prosthecochloris sp. CIB 2401]
MVWTIEFAATAENELSKLDKSAAKRILKFLKERVATDPRSSGKALRGDYARLWRYRIGDYRVICEIRDQTVSVLVVRIGH
RKEVYR

Nucleotide

• Length: 261 bp

>T64623 NZ_CP016432:c560486-560226 [Prosthecochloris sp. CIB 2401]
TTGGTCTGGACGATTGAGTTTGCCGCGACAGCGGAAAATGAATTGTCCAAGTTGGATAAATCTGCGGCAAAGCGGATTCT
CAAATTTCTGAAAGAGCGCGTTGCCACTGATCCCCGCTCATCGGGCAAGGCGTTGCGTGGCGATTATGCCAGACTCTGGC
GGTATCGCATCGGTGATTATCGGGTGATTTGCGAAATCCGGGATCAGACCGTTTCGGTTCTTGTCGTTCGGATCGGGCAT
CGGAAAGAGGTTTATCGGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8594.77 Da
• Isoelectric Point: 4.8605

>AT64623 WP_041702602.1 NZ_CP016432:c560694-560470 [Prosthecochloris sp. CIB 2401]
MIGIRIPKSVGQRLDNLAKRTGRTKTWYVREAIMAHLDDLEDIYLAEQVLERVRRGEEAVSDIDEVERRLGLDD

Nucleotide

• Length: 225 bp

>AT64623 NZ_CP016432:c560694-560470 [Prosthecochloris sp. CIB 2401]
ATGATCGGAATTCGTATTCCGAAGAGCGTGGGTCAACGGCTGGATAACCTTGCAAAAAGAACTGGCCGAACCAAGACCTG
GTATGTTCGCGAGGCGATAATGGCGCACCTCGATGATCTTGAAGACATTTATCTGGCAGAACAGGTTCTCGAACGCGTGA
GGCGTGGAGAAGAGGCTGTGTCCGATATAGATGAAGTGGAGCGTCGTCTTGGTCTGGACGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A5C4S0N8