Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 190492..191162 Replicon chromosome
Accession NZ_CP016432
Organism Prosthecochloris sp. CIB 2401 strain CIB2401

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B1PZG5
Locus tag Ptc2401_RS00910 Protein ID WP_068866057.1
Coordinates 190737..191162 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B1PZP6
Locus tag Ptc2401_RS00905 Protein ID WP_068866056.1
Coordinates 190492..190740 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Ptc2401_RS00885 187278..188150 - 873 WP_139626623.1 hypothetical protein -
Ptc2401_RS00890 188233..188760 - 528 WP_068866053.1 DUF4402 domain-containing protein -
Ptc2401_RS00900 189452..190159 + 708 WP_068866055.1 response regulator transcription factor -
Ptc2401_RS00905 190492..190740 + 249 WP_068866056.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Ptc2401_RS00910 190737..191162 + 426 WP_068866057.1 type II toxin-antitoxin system VapC family toxin Toxin
Ptc2401_RS00915 191347..192582 + 1236 WP_068866058.1 hypothetical protein -
Ptc2401_RS00920 192819..194054 - 1236 WP_083188083.1 integron integrase -
Ptc2401_RS00925 194554..195495 + 942 Protein_171 CoA ester lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-55)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15588.03 Da        Isoelectric Point: 4.7131

>T64621 WP_068866057.1 NZ_CP016432:190737-191162 [Prosthecochloris sp. CIB 2401]
VSYLLDTCVISELVRPVPDERVVRWIESQNEFDLYLSVLTLGEIQKGISKLSHGKKKSTLTAWLKDELEVRFAERVLPVN
DAIALMWGNMLGTSEKNAQPLSVIDALIASTATVHNLVVVTRNISDFSGCSIDILDPCCIS

Download         Length: 426 bp

>T64621 NZ_CP016432:190737-191162 [Prosthecochloris sp. CIB 2401]
GTGAGCTACCTTCTCGATACCTGCGTTATATCCGAACTCGTGCGTCCGGTTCCCGATGAGCGGGTGGTTCGGTGGATCGA
GTCTCAAAACGAATTTGATCTTTACCTGAGTGTACTGACTCTTGGTGAAATCCAGAAGGGAATCTCCAAACTCTCTCATG
GTAAAAAAAAGTCAACGTTGACTGCATGGCTCAAGGATGAACTGGAAGTCCGGTTTGCGGAAAGAGTGCTTCCTGTTAAC
GATGCTATTGCGTTGATGTGGGGGAACATGCTCGGTACCTCAGAAAAAAACGCCCAGCCTCTTTCGGTTATCGATGCGCT
TATTGCCTCAACCGCCACAGTGCATAACCTTGTTGTTGTGACCAGGAATATCTCGGATTTCTCTGGATGCTCCATTGATA
TCCTCGATCCCTGTTGCATCTCCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9733.17 Da        Isoelectric Point: 10.3987

>AT64621 WP_068866056.1 NZ_CP016432:190492-190740 [Prosthecochloris sp. CIB 2401]
MENWQIQKAKNHFSDLVRKAQQEGPQTITRHGKPEAVLLSMKEYRNLMKKQETLTEFFRRSPLHGVTLDLERRKDAAREV
EL

Download         Length: 249 bp

>AT64621 NZ_CP016432:190492-190740 [Prosthecochloris sp. CIB 2401]
ATGGAAAACTGGCAGATACAGAAAGCAAAAAACCATTTCAGCGATCTTGTCCGGAAAGCTCAGCAAGAGGGGCCTCAAAC
CATTACGAGGCACGGAAAACCGGAGGCCGTGCTGCTTTCGATGAAGGAGTATCGTAACCTCATGAAAAAGCAGGAGACGC
TCACGGAATTCTTCCGCCGCTCTCCATTGCACGGGGTGACGCTCGATCTTGAAAGAAGAAAGGATGCAGCCCGGGAGGTA
GAGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1PZG5

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1PZP6

References