Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2804935..2805596 Replicon chromosome
Accession NZ_CP016431
Organism Bordetella bronchiseptica strain I328

Toxin (Protein)


Gene name vapC Uniprot ID A0A807E2K1
Locus tag BBB44_RS13275 Protein ID WP_033448127.1
Coordinates 2805171..2805596 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A807E2N3
Locus tag BBB44_RS13270 Protein ID WP_033448129.1
Coordinates 2804935..2805174 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBB44_RS13235 2799964..2800767 - 804 WP_015063708.1 bacteriocin family protein -
BBB44_RS13240 2800764..2801810 - 1047 WP_015063707.1 Dyp-type peroxidase -
BBB44_RS13245 2801888..2802448 - 561 WP_015063706.1 DUF488 domain-containing protein -
BBB44_RS13250 2802445..2802678 - 234 WP_033447348.1 DUF2945 domain-containing protein -
BBB44_RS13255 2802760..2803272 - 513 WP_033447345.1 redoxin domain-containing protein -
BBB44_RS13260 2803331..2803876 - 546 WP_015063704.1 peroxidase-related enzyme -
BBB44_RS13265 2804020..2804862 + 843 WP_033448135.1 AraC family transcriptional regulator -
BBB44_RS13270 2804935..2805174 + 240 WP_033448129.1 Arc family DNA-binding protein Antitoxin
BBB44_RS13275 2805171..2805596 + 426 WP_033448127.1 PIN domain-containing protein Toxin
BBB44_RS13280 2805706..2806170 + 465 WP_033448125.1 MarR family transcriptional regulator -
BBB44_RS13285 2806267..2807772 - 1506 WP_033448123.1 tripartite tricarboxylate transporter permease -
BBB44_RS13290 2808271..2808783 + 513 WP_033448121.1 hypothetical protein -
BBB44_RS13295 2808803..2809777 - 975 WP_068926360.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14904.22 Da        Isoelectric Point: 5.4757

>T64620 WP_033448127.1 NZ_CP016431:2805171-2805596 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAALSVAEIQLGLARLPRGKRAETLRHEFERRILPLFMGHVLPFDA
AAADAYAAVMTQAAAAGHALDAIDGCIAATATAHGLAIATRHPARFEAAGLTAIDPWQAAV

Download         Length: 426 bp

>T64620 NZ_CP016431:2805171-2805596 [Bordetella bronchiseptica]
ATGATCCTGCTCGATACCGACGTGCTGCTCGAACCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAGACCCTGTACCTGGCCGCGCTCAGCGTGGCCGAGATCCAGCTCGGGCTGGCTCGCCTGCCGCGCGGCA
AGCGGGCCGAGACGCTGCGCCACGAATTCGAGCGGCGCATCCTGCCCCTGTTCATGGGCCATGTCCTGCCTTTCGACGCG
GCCGCGGCCGATGCCTATGCCGCCGTCATGACGCAAGCCGCGGCGGCCGGCCATGCGCTGGACGCGATCGACGGCTGCAT
CGCCGCCACCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCACCCGGCCCGCTTCGAAGCCGCCGGGCTCACCGCCA
TCGACCCCTGGCAAGCCGCCGTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8535.74 Da        Isoelectric Point: 11.5658

>AT64620 WP_033448129.1 NZ_CP016431:2804935-2805174 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARAASFE

Download         Length: 240 bp

>AT64620 NZ_CP016431:2804935-2805174 [Bordetella bronchiseptica]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTGCGCGCCGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGACGGGCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGATCTGACCATCGAACGCAACCCGGCGCCCGCCCGCGCGGCCAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807E2K1

Antitoxin

Source ID Structure
AlphaFold DB A0A807E2N3

References