Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 313631..314159 Replicon chromosome
Accession NZ_CP016415
Organism Vibrio scophthalmi strain VS-05

Toxin (Protein)


Gene name relE Uniprot ID A0A1C7FEF6
Locus tag VSVS05_RS15940 Protein ID WP_065546184.1
Coordinates 313631..313921 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1C7FF14
Locus tag VSVS05_RS15945 Protein ID WP_065546185.1
Coordinates 313911..314159 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VSVS05_RS15920 310155..310652 + 498 WP_065546181.1 ATP-binding protein -
VSVS05_RS15925 310723..311754 - 1032 WP_175422461.1 IS630 family transposase -
VSVS05_RS15930 311892..312392 + 501 WP_083163627.1 GNAT family N-acetyltransferase -
VSVS05_RS15935 312542..312925 + 384 WP_065546183.1 hypothetical protein -
VSVS05_RS15940 313631..313921 - 291 WP_065546184.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VSVS05_RS15945 313911..314159 - 249 WP_065546185.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VSVS05_RS15950 314357..314761 + 405 WP_065546186.1 GFA family protein -
VSVS05_RS15955 314902..315402 + 501 WP_083163632.1 GNAT family N-acetyltransferase -
VSVS05_RS15960 315548..315925 + 378 WP_065546188.1 hypothetical protein -
VSVS05_RS15965 316062..316580 + 519 Protein_264 GNAT family N-acetyltransferase -
VSVS05_RS15970 316692..317021 + 330 WP_065546189.1 DHCW motif cupin fold protein -
VSVS05_RS15975 317768..318121 + 354 WP_065546190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 261900..321234 59334
- flank IS/Tn - - 310723..311754 1031
- inside Integron - - 258747..321234 62487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11117.04 Da        Isoelectric Point: 10.7148

>T64617 WP_065546184.1 NZ_CP016415:c313921-313631 [Vibrio scophthalmi]
MTYNLEFKSSALKEWKKLGATLQQQFKKKLIERLANPHVPASKLSGADNMYKIKLRQSGYRLVYKVQDDVVIVTVLAVGK
RERSDVYRKAMTRLND

Download         Length: 291 bp

>T64617 NZ_CP016415:c313921-313631 [Vibrio scophthalmi]
ATGACTTATAATCTTGAATTTAAAAGTAGCGCACTTAAAGAGTGGAAAAAACTCGGCGCTACTTTGCAACAGCAATTTAA
GAAGAAACTGATTGAGCGCTTAGCTAACCCACACGTTCCTGCTTCCAAATTATCCGGCGCAGACAACATGTATAAGATCA
AATTACGCCAATCTGGCTATCGCTTAGTATACAAAGTGCAAGACGATGTAGTTATTGTTACCGTTTTAGCCGTAGGTAAG
CGCGAACGTAGCGATGTGTACAGAAAAGCGATGACAAGGCTCAACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8840.18 Da        Isoelectric Point: 4.1225

>AT64617 WP_065546185.1 NZ_CP016415:c314159-313911 [Vibrio scophthalmi]
MTARILADVAASITEFKANPMKVASSAYGAPVAVLNRNEPAFYCVPAAAYEMMMDKLEDIELLALAKERESEASISVSID
DL

Download         Length: 249 bp

>AT64617 NZ_CP016415:c314159-313911 [Vibrio scophthalmi]
ATGACCGCTAGAATATTAGCTGATGTTGCTGCAAGTATTACTGAGTTTAAAGCGAACCCAATGAAGGTTGCTTCAAGCGC
TTATGGTGCTCCAGTCGCTGTACTAAACCGAAATGAACCTGCATTTTACTGTGTACCTGCTGCTGCATACGAAATGATGA
TGGACAAGCTTGAAGATATTGAGCTGCTAGCTTTAGCTAAAGAGCGAGAATCTGAAGCAAGCATTTCGGTGAGTATCGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7FEF6

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7FF14

References