Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 288665..289214 Replicon chromosome
Accession NZ_CP016415
Organism Vibrio scophthalmi strain VS-05

Toxin (Protein)


Gene name parE Uniprot ID A0A1C7FEY7
Locus tag VSVS05_RS15795 Protein ID WP_065546161.1
Coordinates 288665..288964 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7FEU7
Locus tag VSVS05_RS15800 Protein ID WP_045101727.1
Coordinates 288972..289214 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VSVS05_RS15775 284493..284783 + 291 WP_156785357.1 hypothetical protein -
VSVS05_RS15780 284984..285688 + 705 WP_017064048.1 HNH endonuclease -
VSVS05_RS15785 285714..286682 - 969 WP_083163595.1 IS30 family transposase -
VSVS05_RS15790 287576..288490 + 915 WP_065546160.1 alpha/beta hydrolase -
VSVS05_RS15795 288665..288964 - 300 WP_065546161.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VSVS05_RS15800 288972..289214 - 243 WP_045101727.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VSVS05_RS15805 290039..290572 + 534 WP_065546162.1 hypothetical protein -
VSVS05_RS15815 291867..292325 + 459 WP_065546164.1 hypothetical protein -
VSVS05_RS15820 292473..293156 + 684 WP_065546806.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 261900..321234 59334
- flank IS/Tn - - 285714..286646 932
- inside Integron - - 258747..321234 62487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11423.16 Da        Isoelectric Point: 10.0236

>T64616 WP_065546161.1 NZ_CP016415:c288964-288665 [Vibrio scophthalmi]
MHKSKYKLSKLAQAHLHKIKNYTVINFSQMQWNSYKDTLLTGFQMLAENPAVGRSCNDIYQNGFYFPIGKHTAYFTKEDG
FILVVAVLGQSQLPQNHLR

Download         Length: 300 bp

>T64616 NZ_CP016415:c288964-288665 [Vibrio scophthalmi]
ATGCACAAGAGCAAATATAAACTAAGTAAATTAGCACAGGCTCATTTACACAAAATCAAAAATTATACTGTTATAAACTT
TTCCCAGATGCAGTGGAACTCATATAAAGACACTCTTCTTACTGGGTTTCAGATGCTTGCTGAAAACCCGGCAGTAGGTA
GAAGCTGCAACGATATATATCAAAACGGTTTTTACTTCCCGATCGGTAAGCACACGGCTTACTTTACCAAAGAAGACGGC
TTTATTTTGGTCGTTGCAGTTCTTGGACAATCGCAATTACCGCAAAACCATTTGCGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8981.20 Da        Isoelectric Point: 4.7672

>AT64616 WP_045101727.1 NZ_CP016415:c289214-288972 [Vibrio scophthalmi]
MYTLTANDAKRNFGELLLNAQREPVKISKNNKDAVVVMSIRDYEELEAMKADYIKHCFETAKADLAQGNVVDGENFLSAL

Download         Length: 243 bp

>AT64616 NZ_CP016415:c289214-288972 [Vibrio scophthalmi]
ATGTACACATTAACAGCAAATGACGCTAAACGTAATTTCGGTGAACTGCTTCTAAACGCTCAACGCGAGCCAGTTAAAAT
TAGTAAAAACAACAAAGATGCCGTTGTTGTAATGTCGATTAGAGACTATGAAGAACTTGAAGCGATGAAAGCCGATTACA
TAAAACATTGCTTTGAGACTGCAAAAGCAGACTTAGCCCAAGGCAATGTCGTTGATGGTGAAAATTTCTTAAGCGCGTTG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7FEY7

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7FEU7

References