Detailed information of TA system TA064614

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 49897..50422
• Replicon: plasmid pCVM44454
• Accession: NZ_CP016413
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain CVM44454

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A5Y5FBU7
• Locus tag: BAR51_RS24200
• Protein ID: WP_023994134.1
• Coordinates: 50117..50422 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A5T8X4Y4
• Locus tag: BAR51_RS24195
• Protein ID: WP_023994135.1
• Coordinates: 49897..50115 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAR51_RS24150	44929..45693	+	765	WP_023994141.1	minor fimbrial protein	-
BAR51_RS24155	45743..45895	+	153	Protein_54	fimbrial protein	-
BAR51_RS24160	45896..46486	+	591	WP_023994140.1	hypothetical protein	-
BAR51_RS24165	46552..46764	+	213	WP_023994139.1	PefI	-
BAR51_RS24170	47212..48060	+	849	WP_023994138.1	SdiA-regulated domain-containing protein	-
BAR51_RS24175	48135..48422	-	288	WP_071790428.1	hypothetical protein	-
BAR51_RS24185	48630..49046	-	417	WP_023994137.1	type II toxin-antitoxin system VapC family toxin	-
BAR51_RS24190	49043..49273	-	231	WP_023994136.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
BAR51_RS26085	49327..49723	+	397	Protein_61	hypothetical protein	-
BAR51_RS24195	49897..50115	+	219	WP_023994135.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
BAR51_RS24200	50117..50422	+	306	WP_023994134.1	type II toxin-antitoxin system toxin CcdB	Toxin
BAR51_RS24205	50424..50714	+	291	WP_023994133.1	hypothetical protein	-
BAR51_RS26515	50711..51061	+	351	Protein_65	3'-5' exonuclease	-
BAR51_RS24215	51087..51173	+	87	Protein_66	cytoplasmic protein	-
BAR51_RS26090	51163..51878	-	716	Protein_67	transposase	-
BAR51_RS24230	53160..53696	+	537	WP_023994130.1	fimbrial protein	-
BAR51_RS24235	53818..54480	+	663	WP_077914829.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..316160	316160

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (3-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-93)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T64614 WP_023994134.1 NZ_CP016413:50117-50422 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T64614 NZ_CP016413:50117-50422 [Salmonella enterica subsp. enterica serovar Infantis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT64614 WP_023994135.1 NZ_CP016413:49897-50115 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT64614 NZ_CP016413:49897-50115 [Salmonella enterica subsp. enterica serovar Infantis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A5Y5FBU7

Antitoxin

• AlphaFold DB: A0A5T8X4Y4