Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 48630..49273 Replicon plasmid pCVM44454
Accession NZ_CP016413
Organism Salmonella enterica subsp. enterica serovar Infantis strain CVM44454

Toxin (Protein)


Gene name vagD Uniprot ID A0A5T8FJ24
Locus tag BAR51_RS24185 Protein ID WP_023994137.1
Coordinates 48630..49046 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5T3Q059
Locus tag BAR51_RS24190 Protein ID WP_023994136.1
Coordinates 49043..49273 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAR51_RS24145 44110..44901 + 792 WP_023994142.1 F4 (K88) fimbria minor subunit FaeH -
BAR51_RS24150 44929..45693 + 765 WP_023994141.1 minor fimbrial protein -
BAR51_RS24155 45743..45895 + 153 Protein_54 fimbrial protein -
BAR51_RS24160 45896..46486 + 591 WP_023994140.1 hypothetical protein -
BAR51_RS24165 46552..46764 + 213 WP_023994139.1 PefI -
BAR51_RS24170 47212..48060 + 849 WP_023994138.1 SdiA-regulated domain-containing protein -
BAR51_RS24175 48135..48422 - 288 WP_071790428.1 hypothetical protein -
BAR51_RS24185 48630..49046 - 417 WP_023994137.1 type II toxin-antitoxin system VapC family toxin Toxin
BAR51_RS24190 49043..49273 - 231 WP_023994136.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BAR51_RS26085 49327..49723 + 397 Protein_61 hypothetical protein -
BAR51_RS24195 49897..50115 + 219 WP_023994135.1 type II toxin-antitoxin system antitoxin CcdA -
BAR51_RS24200 50117..50422 + 306 WP_023994134.1 type II toxin-antitoxin system toxin CcdB -
BAR51_RS24205 50424..50714 + 291 WP_023994133.1 hypothetical protein -
BAR51_RS26515 50711..51061 + 351 Protein_65 3'-5' exonuclease -
BAR51_RS24215 51087..51173 + 87 Protein_66 cytoplasmic protein -
BAR51_RS26090 51163..51878 - 716 Protein_67 transposase -
BAR51_RS24230 53160..53696 + 537 WP_023994130.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..316160 316160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(1-32)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 20475.56 Da        Isoelectric Point: 5.5500

>T64613 WP_023994137.1 NZ_CP016413:c49046-48630 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 417 bp

>T64613 NZ_CP016413:c49046-48630 [Salmonella enterica subsp. enterica serovar Infantis]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT64613 WP_023994136.1 NZ_CP016413:c49273-49043 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT64613 NZ_CP016413:c49273-49043 [Salmonella enterica subsp. enterica serovar Infantis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FJ24

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q059

References