Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 14531..15121 Replicon plasmid pCVM44454
Accession NZ_CP016413
Organism Salmonella enterica subsp. enterica serovar Infantis strain CVM44454

Toxin (Protein)


Gene name pemK Uniprot ID A0A241PXU0
Locus tag BAR51_RS23940 Protein ID WP_023994178.1
Coordinates 14789..15121 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A5T3Q5H6
Locus tag BAR51_RS23935 Protein ID WP_023994179.1
Coordinates 14531..14788 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAR51_RS23920 10018..11055 + 1038 WP_031619582.1 IS630 family transposase -
BAR51_RS23925 11065..13920 - 2856 Protein_10 hypothetical protein -
BAR51_RS23930 14157..14571 - 415 Protein_11 hypothetical protein -
BAR51_RS23935 14531..14788 + 258 WP_023994179.1 hypothetical protein Antitoxin
BAR51_RS23940 14789..15121 + 333 WP_023994178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BAR51_RS23945 15354..15548 + 195 WP_110613430.1 hypothetical protein -
BAR51_RS23950 15721..16326 + 606 Protein_15 IS481 family transposase -
BAR51_RS23955 16625..18847 - 2223 WP_023994175.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..316160 316160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 14245.34 Da        Isoelectric Point: 12.8414

>T64611 WP_023994178.1 NZ_CP016413:14789-15121 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 333 bp

>T64611 NZ_CP016413:14789-15121 [Salmonella enterica subsp. enterica serovar Infantis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 11040.99 Da        Isoelectric Point: 12.7294

>AT64611 WP_023994179.1 NZ_CP016413:14531-14788 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKK

Download         Length: 258 bp

>AT64611 NZ_CP016413:14531-14788 [Salmonella enterica subsp. enterica serovar Infantis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXU0

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q5H6

References