Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 49897..50422 Replicon plasmid pN55391
Accession NZ_CP016411
Organism Salmonella enterica subsp. enterica serovar Infantis strain N55391

Toxin (Protein)


Gene name ccdB Uniprot ID A0A5Y5FBU7
Locus tag APL92_RS24195 Protein ID WP_023994134.1
Coordinates 50117..50422 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A5T8X4Y4
Locus tag APL92_RS24190 Protein ID WP_023994135.1
Coordinates 49897..50115 (+) Length 73 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APL92_RS24145 44929..45693 + 765 WP_023994141.1 minor fimbrial protein -
APL92_RS24155 45896..46486 + 591 WP_023994140.1 hypothetical protein -
APL92_RS24160 46552..46764 + 213 WP_023994139.1 PefI -
APL92_RS26730 47025..47186 + 162 WP_001816720.1 hypothetical protein -
APL92_RS24165 47212..48060 + 849 WP_023994138.1 SdiA-regulated domain-containing protein -
APL92_RS24180 48630..49046 - 417 WP_023994137.1 type II toxin-antitoxin system VapC family toxin -
APL92_RS24185 49043..49273 - 231 WP_023994136.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
APL92_RS24190 49897..50115 + 219 WP_023994135.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
APL92_RS24195 50117..50422 + 306 WP_023994134.1 type II toxin-antitoxin system toxin CcdB Toxin
APL92_RS24200 50424..50714 + 291 WP_023994133.1 hypothetical protein -
APL92_RS26505 50711..51061 + 351 Protein_58 3'-5' exonuclease -
APL92_RS24210 51087..51173 + 87 Protein_59 cytoplasmic protein -
APL92_RS26095 51163..51878 - 716 Protein_60 transposase -
APL92_RS24225 53160..53696 + 537 WP_023994130.1 fimbrial protein -
APL92_RS24230 53749..54480 + 732 WP_023994129.1 fimbria/pilus periplasmic chaperone -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..316814 316814


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T64609 WP_023994134.1 NZ_CP016411:50117-50422 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T64609 NZ_CP016411:50117-50422 [Salmonella enterica subsp. enterica serovar Infantis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT64609 WP_023994135.1 NZ_CP016411:49897-50115 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT64609 NZ_CP016411:49897-50115 [Salmonella enterica subsp. enterica serovar Infantis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5Y5FBU7


Antitoxin

Source ID Structure
AlphaFold DB A0A5T8X4Y4

References