Detailed information of TA system TA064598

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 48630..49273
• Replicon: plasmid pFSIS1502169
• Accession: NZ_CP016407
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain FSIS1502169

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: A0A5T8FJ24
• Locus tag: ATD18_RS24185
• Protein ID: WP_023994137.1
• Coordinates: 48630..49046 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A5T3Q059
• Locus tag: ATD18_RS24190
• Protein ID: WP_023994136.1
• Coordinates: 49043..49273 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATD18_RS24145	44110..44901	+	792	WP_023994142.1	F4 (K88) fimbria minor subunit FaeH	-
ATD18_RS24150	44929..45693	+	765	WP_023994141.1	minor fimbrial protein	-
ATD18_RS24160	45896..46486	+	591	WP_023994140.1	hypothetical protein	-
ATD18_RS24165	46552..46764	+	213	WP_023994139.1	PefI	-
ATD18_RS26825	47025..47186	+	162	WP_001816720.1	hypothetical protein	-
ATD18_RS24170	47212..48060	+	849	WP_023994138.1	SdiA-regulated domain-containing protein	-
ATD18_RS24185	48630..49046	-	417	WP_023994137.1	type II toxin-antitoxin system VapC family toxin	Toxin
ATD18_RS24190	49043..49273	-	231	WP_023994136.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
ATD18_RS24195	49897..50115	+	219	WP_023994135.1	type II toxin-antitoxin system antitoxin CcdA	-
ATD18_RS24200	50117..50422	+	306	WP_023994134.1	type II toxin-antitoxin system toxin CcdB	-
ATD18_RS24205	50424..50714	+	291	WP_023994133.1	hypothetical protein	-
ATD18_RS26610	50711..51061	+	351	Protein_58	3'-5' exonuclease	-
ATD18_RS24215	51087..51173	+	87	Protein_59	cytoplasmic protein	-
ATD18_RS26180	51163..51878	-	716	Protein_60	transposase	-
ATD18_RS24230	53160..53696	+	537	WP_023994130.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..323122	323122

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (13-50)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 20475.56 Da
• Isoelectric Point: 5.5500

>T64598 WP_023994137.1 NZ_CP016407:c49046-48630 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 417 bp

>T64598 NZ_CP016407:c49046-48630 [Salmonella enterica subsp. enterica serovar Infantis]
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Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 11350.61 Da
• Isoelectric Point: 5.5500

>AT64598 WP_023994136.1 NZ_CP016407:c49273-49043 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 231 bp

>AT64598 NZ_CP016407:c49273-49043 [Salmonella enterica subsp. enterica serovar Infantis]
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Structures

Toxin

• AlphaFold DB: A0A5T8FJ24

Antitoxin

• AlphaFold DB: A0A5T3Q059