64556

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 838690..839167 Replicon chromosome
Accession NZ_CP016398
Organism Staphylococcus aureus strain FORC_040

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FORC40_RS04160 Protein ID WP_000052076.1
Coordinates 838690..838878 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FORC40_RS04165 Protein ID WP_001059690.1
Coordinates 838907..839167 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC40_RS04130 834680..835201 + 522 WP_000824484.1 hypothetical protein -
FORC40_RS04135 835542..836228 + 687 WP_001792695.1 thermonuclease family protein -
FORC40_RS04140 836585..836785 + 201 WP_001059082.1 cold-shock protein -
FORC40_RS04145 837281..837499 - 219 WP_000005886.1 hypothetical protein -
FORC40_RS04150 837561..837845 - 285 WP_001004395.1 hypothetical protein -
FORC40_RS04155 837933..838502 - 570 WP_001106654.1 hypothetical protein -
FORC40_RS04160 838690..838878 - 189 WP_000052076.1 hypothetical protein Toxin
FORC40_RS04165 838907..839167 - 261 WP_001059690.1 hypothetical protein Antitoxin
FORC40_RS04170 839508..839711 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FORC40_RS04175 839708..839944 - 237 WP_000368687.1 hypothetical protein -
FORC40_RS04180 840169..840750 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
FORC40_RS04185 840823..841440 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
FORC40_RS04190 841595..842089 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FORC40_RS04195 842488..842910 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FORC40_RS04200 843058..843774 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T64556 WP_000052076.1 NZ_CP016398:c838878-838690 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T64556 NZ_CP016398:c838878-838690 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT64556 WP_001059690.1 NZ_CP016398:c839167-838907 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT64556 NZ_CP016398:c839167-838907 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References