Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2251737..2253289 Replicon chromosome
Accession NZ_CP016397
Organism Legionella clemsonensis strain CDC-D5610

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag clem_RS09850 Protein ID WP_094091394.1
Coordinates 2251982..2253289 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag clem_RS09845 Protein ID WP_094091393.1
Coordinates 2251737..2251988 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
clem_RS09830 2247942..2249132 + 1191 WP_094091392.1 multidrug effflux MFS transporter -
clem_RS09835 2249358..2250527 + 1170 WP_094092332.1 Na+/H+ antiporter NhaA -
clem_RS09840 2250576..2251505 + 930 WP_094092333.1 universal stress protein -
clem_RS09845 2251737..2251988 + 252 WP_094091393.1 helix-turn-helix transcriptional regulator Antitoxin
clem_RS09850 2251982..2253289 + 1308 WP_094091394.1 type II toxin-antitoxin system HipA family toxin Toxin
clem_RS09855 2253331..2255439 - 2109 WP_157698227.1 FUSC family protein -
clem_RS09860 2255405..2256409 - 1005 WP_094091396.1 HlyD family secretion protein -
clem_RS09865 2256538..2258250 + 1713 WP_094091397.1 NAD-dependent malic enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50285.26 Da        Isoelectric Point: 8.4527

>T64555 WP_094091394.1 NZ_CP016397:2251982-2253289 [Legionella clemsonensis]
MVKRKQILHVLMNGILIGDLEKTFQGGLRFTYYYEWLNRPGARPISLSLPLIQQTYTGDVVYNFFDNLLPDNQQIRTRIQ
AKFQIPTNQPFDLLSSIGRDCVGAIQLIDGQLPEFKKKINFKPLTEQSIAAKLKNYHVNPLGMSNKDQDFRISIAGAQEK
TAFLYHQHQWCEPLQDTPTTHIFKLPIGFISHQNIDLSDSCENEWLCSLIAKSFGLLVAECEILHFEEVKVLSVERFDRR
ISHDKSWIMRLPQEDMCQALGVSHSLKYQSDGGPGIKEIMKLLLGSTMPMEDRDCFYRAQVFFWLIAGIDGHAKNFSLFI
EPEGKYRLTPLYDIMSAYPLIKKKQLQTQKIKMAMALQGKNTHYHWYTLQRRHFIETAKAVSYSVEKAECILDEMLKKTE
SVIEEVSKQLPANFPIHISEPIFEGIQKAKHRLNR

Download         Length: 1308 bp

>T64555 NZ_CP016397:2251982-2253289 [Legionella clemsonensis]
ATGGTAAAACGAAAGCAAATTCTTCATGTCTTAATGAATGGCATTCTAATAGGAGACTTGGAAAAAACATTTCAAGGGGG
GTTAAGGTTTACTTACTATTACGAATGGCTAAACCGCCCAGGTGCCCGACCTATTTCTTTGTCACTTCCACTCATTCAGC
AAACTTACACGGGTGATGTGGTTTATAATTTTTTTGACAACCTTCTTCCAGACAATCAACAAATACGTACTAGGATTCAG
GCTAAATTTCAAATACCCACTAATCAACCTTTTGACTTGCTTTCAAGCATTGGCAGGGATTGTGTAGGGGCAATCCAGCT
CATTGATGGCCAACTACCCGAATTTAAAAAAAAAATAAATTTTAAACCCTTAACGGAACAAAGCATTGCCGCCAAATTAA
AAAATTATCACGTTAATCCATTGGGGATGAGTAATAAGGATCAGGATTTTAGGATCTCTATTGCCGGAGCACAGGAAAAA
ACTGCATTTTTATATCATCAACATCAATGGTGCGAACCACTGCAAGACACACCAACCACCCATATTTTTAAGTTACCAAT
TGGTTTCATTTCTCATCAAAATATAGATTTAAGTGATAGTTGCGAAAATGAATGGCTATGCTCTCTCATTGCTAAAAGTT
TTGGACTTCTAGTGGCCGAATGTGAAATCTTGCACTTTGAAGAGGTGAAAGTTTTATCCGTCGAACGATTTGATCGCCGT
ATCTCTCATGATAAGAGCTGGATAATGCGATTGCCTCAAGAGGATATGTGTCAAGCATTGGGTGTCTCTCATAGCCTCAA
ATACCAATCAGATGGCGGTCCTGGCATAAAAGAGATCATGAAACTGCTGTTAGGTTCTACAATGCCCATGGAAGATAGGG
ATTGTTTTTACCGGGCTCAGGTTTTCTTCTGGTTAATTGCCGGCATTGATGGTCATGCCAAGAACTTCAGTTTATTTATT
GAGCCTGAAGGAAAATATCGGCTAACACCCTTATATGATATTATGTCAGCCTATCCCCTAATAAAGAAAAAACAACTACA
AACTCAAAAAATAAAAATGGCAATGGCATTACAGGGTAAAAATACTCATTACCATTGGTACACTCTGCAGCGCCGCCATT
TTATAGAAACAGCAAAAGCTGTCAGTTACTCAGTTGAGAAAGCTGAATGTATCCTTGACGAAATGCTAAAAAAAACAGAA
TCAGTAATAGAAGAAGTCTCCAAACAATTACCCGCAAACTTCCCAATACATATCTCTGAACCTATTTTTGAAGGAATTCA
AAAGGCTAAACACAGATTAAACAGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9513.13 Da        Isoelectric Point: 10.3930

>AT64555 WP_094091393.1 NZ_CP016397:2251737-2251988 [Legionella clemsonensis]
MLIHSPHELAMLLKNRRKLLKLNQAQVGSLVGLKQKTISAIENNAENIRLNTLFRILSALDLDINISPKNEINIVAKQWN
DEW

Download         Length: 252 bp

>AT64555 NZ_CP016397:2251737-2251988 [Legionella clemsonensis]
ATGCTTATTCATTCACCGCATGAACTAGCAATGCTACTAAAAAATCGACGCAAATTATTAAAATTAAATCAAGCTCAAGT
AGGTAGTCTTGTGGGTCTAAAACAAAAAACAATTTCTGCTATTGAAAACAATGCAGAAAATATCAGGTTGAATACTTTAT
TTCGAATATTATCTGCTCTTGATTTAGATATAAATATCTCGCCTAAAAATGAAATCAATATAGTAGCCAAACAATGGAAT
GATGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References