Detailed information of TA system TA064553

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/ParD(antitoxin)
• Location: 4493541..4494539
• Replicon: chromosome
• Accession: NZ_CP016396
• Organism: Mycobacterium avium strain RCAD0278 isolate SC150824

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: X7VT18
• Locus tag: BBJ32_RS20730
• Protein ID: WP_003876749.1
• Coordinates: 4493961..4494539 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A049EEK5
• Locus tag: BBJ32_RS20725
• Protein ID: WP_009976725.1
• Coordinates: 4493541..4493930 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBJ32_RS20705	4488677..4489357	-	681	WP_023861532.1	hypothetical protein	-
BBJ32_RS20710	4489436..4490953	+	1518	WP_009976720.1	carboxylesterase/lipase family protein	-
BBJ32_RS20715	4490972..4492969	+	1998	WP_003876752.1	phosphotransferase	-
BBJ32_RS20720	4492966..4493460	+	495	WP_023884347.1	gluconokinase	-
BBJ32_RS20725	4493541..4493930	+	390	WP_009976725.1	hypothetical protein	Antitoxin
BBJ32_RS20730	4493961..4494539	+	579	WP_003876749.1	zeta toxin family protein	Toxin
BBJ32_RS20735	4494544..4495545	-	1002	WP_065371137.1	DoxX family membrane protein	-
BBJ32_RS20740	4495656..4496216	+	561	WP_155251422.1	pyrazinamidase PncA	-
BBJ32_RS20745	4496216..4497016	+	801	WP_031354786.1	nuclear transport factor 2 family protein	-
BBJ32_RS20750	4497030..4497380	-	351	WP_003878038.1	DoxX family protein	-
BBJ32_RS20755	4497549..4498481	+	933	WP_009976731.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21034.18 Da
• Isoelectric Point: 10.6678

>T64553 WP_003876749.1 NZ_CP016396:4493961-4494539 [Mycobacterium avium]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Nucleotide

• Length: 579 bp

>T64553 NZ_CP016396:4493961-4494539 [Mycobacterium avium]
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATCGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCACGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTGGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13598.04 Da
• Isoelectric Point: 5.6717

>AT64553 WP_009976725.1 NZ_CP016396:4493541-4493930 [Mycobacterium avium]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTVEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Nucleotide

• Length: 390 bp

>AT64553 NZ_CP016396:4493541-4493930 [Mycobacterium avium]
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGATCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAACTCACCGTCGAAGAGGGCGTGGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGATGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A0E2W6B4

Antitoxin

• AlphaFold DB: A0A049EEK5