Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 4198372..4199033 Replicon chromosome
Accession NZ_CP016396
Organism Mycobacterium avium strain RCAD0278 isolate SC150824

Toxin (Protein)


Gene name vapC Uniprot ID A0A049E7F1
Locus tag BBJ32_RS19490 Protein ID WP_023879930.1
Coordinates 4198629..4199033 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A049EBE1
Locus tag BBJ32_RS19485 Protein ID WP_009976405.1
Coordinates 4198372..4198632 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBJ32_RS19465 4193786..4194448 + 663 WP_009976400.1 TetR/AcrR family transcriptional regulator -
BBJ32_RS19470 4194643..4196103 + 1461 WP_009976402.1 serine/threonine protein kinase -
BBJ32_RS19475 4196305..4197573 - 1269 WP_023884275.1 cytochrome P450 -
BBJ32_RS19480 4197739..4198191 + 453 WP_029248457.1 VOC family protein -
BBJ32_RS19485 4198372..4198632 + 261 WP_009976405.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BBJ32_RS19490 4198629..4199033 + 405 WP_023879930.1 type II toxin-antitoxin system VapC family toxin Toxin
BBJ32_RS23260 4199180..4200745 - 1566 WP_081304387.1 serine/threonine protein kinase -
BBJ32_RS19495 4200982..4201503 + 522 WP_009976411.1 carboxymuconolactone decarboxylase family protein -
BBJ32_RS19500 4201500..4202045 + 546 WP_009976412.1 carboxymuconolactone decarboxylase family protein -
BBJ32_RS19505 4202166..4202696 + 531 WP_011724637.1 TetR/AcrR family transcriptional regulator -
BBJ32_RS19510 4202685..4203854 - 1170 WP_009976416.1 acyl-CoA dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14329.33 Da        Isoelectric Point: 4.5860

>T64552 WP_023879930.1 NZ_CP016396:4198629-4199033 [Mycobacterium avium]
MTARPAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAARM
WARLRIHLAEAGRRMRANDLWIAGIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 405 bp

>T64552 NZ_CP016396:4198629-4199033 [Mycobacterium avium]
ATGACTGCAAGGCCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCACCTGGACGAGGCGCG
AATCCCCGACGAGGTAGCCACCACCGTCATCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCGACG
TTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGTTGCCAGTCGACGACGACGCGGCCCGCATG
TGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGGGATCGCGGC
ATCGCGGGGACTGCCCGTTGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTCGGG
TTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9495.81 Da        Isoelectric Point: 11.4633

>AT64552 WP_009976405.1 NZ_CP016396:4198372-4198632 [Mycobacterium avium]
MSEVASRELRNDTAGVLRRVREGEDVTITVNGRAVAMLTALGPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT64552 NZ_CP016396:4198372-4198632 [Mycobacterium avium]
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTGCGGGAAGGGGAGGACGTCAC
CATCACCGTCAACGGCCGAGCCGTCGCGATGCTGACCGCGCTGGGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACAACTGAG
GACCTCGGTCCGATCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A049E7F1

Antitoxin

Source ID Structure
AlphaFold DB A0A049EBE1

References