Detailed information of TA system TA064544

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/Xre(antitoxin)
• Location: 23354..23855
• Replicon: plasmid p931IncI2
• Accession: NZ_CP016388
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain ST931R

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: A0A6X6XTU7
• Locus tag: BBC45_RS24185
• Protein ID: WP_000702245.1
• Coordinates: 23354..23614 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: -
• Locus tag: BBC45_RS26870
• Protein ID: WP_001132407.1
• Coordinates: 23604..23855 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBC45_RS24140	18950..19111	+	162	WP_001434039.1	type I toxin-antitoxin system Hok family toxin	-
BBC45_RS24145	19261..19857	+	597	WP_000125164.1	hypothetical protein	-
BBC45_RS28075	19875..20159	-	285	WP_001162371.1	hypothetical protein	-
BBC45_RS24155	20233..20898	-	666	WP_000532148.1	P-loop NTPase	-
BBC45_RS24160	21497..21826	+	330	WP_000855121.1	hypothetical protein	-
BBC45_RS24170	22407..22730	+	324	WP_000427402.1	hypothetical protein	-
BBC45_RS24175	22771..22980	+	210	WP_000866037.1	hypothetical protein	-
BBC45_RS24180	23078..23302	+	225	WP_000814383.1	hypothetical protein	-
BBC45_RS24185	23354..23614	+	261	WP_000702245.1	hypothetical protein	Toxin
BBC45_RS26870	23604..23855	+	252	WP_001132407.1	transcriptional regulator	Antitoxin
BBC45_RS24195	24405..24683	+	279	WP_000545937.1	hypothetical protein	-
BBC45_RS24200	25070..25252	-	183	WP_001401700.1	hypothetical protein	-
BBC45_RS26880	25810..25992	+	183	WP_071961619.1	type II toxin-antitoxin system HicA family toxin	-
BBC45_RS24205	26017..26454	+	438	WP_000466318.1	type II toxin-antitoxin system HicB family antitoxin	-
BBC45_RS24210	26584..26904	-	321	WP_001401701.1	hypothetical protein	-
BBC45_RS24215	26901..27416	-	516	WP_001229210.1	hypothetical protein	-
BBC45_RS24220	27418..27621	-	204	WP_000224735.1	hypothetical protein	-
BBC45_RS24225	27627..28064	-	438	WP_000206706.1	hypothetical protein	-
BBC45_RS24230	28084..28791	-	708	WP_000108795.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..60496	60496

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-150)

Antitoxin

• PrlF antitoxin (14-110)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 11169.16 Da
• Isoelectric Point: 12.7344

>T64544 WP_000702245.1 NZ_CP016388:23354-23614 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKK

Nucleotide

• Length: 261 bp

>T64544 NZ_CP016388:23354-23614 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT64544 WP_001132407.1 NZ_CP016388:23604-23855 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT64544 NZ_CP016388:23604-23855 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A6X6XTU7