Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 19606..20165 Replicon plasmid p931IncI1
Accession NZ_CP016387
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ST931R

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag BBC45_RS23640 Protein ID WP_000421259.1
Coordinates 19606..19881 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U0BV64
Locus tag BBC45_RS23645 Protein ID WP_001178090.1
Coordinates 19881..20165 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBC45_RS23605 15324..15578 + 255 WP_000343107.1 hypothetical protein -
BBC45_RS23610 15578..16168 + 591 WP_001306774.1 hypothetical protein -
BBC45_RS23615 16381..17433 + 1053 WP_000655519.1 hypothetical protein -
BBC45_RS23620 17609..18211 + 603 WP_000521606.1 hypothetical protein -
BBC45_RS23625 18267..18761 + 495 WP_015058884.1 hypothetical protein -
BBC45_RS23630 18761..19027 + 267 WP_000627832.1 hypothetical protein -
BBC45_RS23635 19219..19500 - 282 WP_001105066.1 hypothetical protein -
BBC45_RS23640 19606..19881 - 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BBC45_RS23645 19881..20165 - 285 WP_001178090.1 ribbon-helix-helix protein, CopG family Antitoxin
BBC45_RS23650 21071..22102 - 1032 WP_022630251.1 replication initiation protein -
BBC45_RS26740 23075..23338 + 264 WP_001749178.1 ash family protein -
BBC45_RS23655 23256..23543 + 288 WP_000074855.1 conjugal transfer protein TraA -
BBC45_RS23660 23985..24518 + 534 WP_001372168.1 transcription termination factor NusG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93202 93202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 13558.26 Da        Isoelectric Point: 5.5500

>T64543 WP_000421259.1 NZ_CP016387:c19881-19606 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFF

Download         Length: 276 bp

>T64543 NZ_CP016387:c19881-19606 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 13999.79 Da        Isoelectric Point: 5.5500

>AT64543 WP_001178090.1 NZ_CP016387:c20165-19881 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFF

Download         Length: 285 bp

>AT64543 NZ_CP016387:c20165-19881 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YB49

Antitoxin

Source ID Structure
AlphaFold DB A0A7U0BV64

References