Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-Phd |
| Location | 30428..30975 | Replicon | chromosome |
| Accession | NZ_CP016384 | ||
| Organism | Vibrio mimicus strain SCCF01 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0Q0PYS1 |
| Locus tag | vm_RS15315 | Protein ID | WP_000229322.1 |
| Coordinates | 30673..30975 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KM93 |
| Locus tag | vm_RS15310 | Protein ID | WP_000861987.1 |
| Coordinates | 30428..30685 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| vm_RS21200 | 25871..25960 | + | 90 | WP_196770055.1 | DUF3265 domain-containing protein | - |
| vm_RS15270 | 26006..26401 | + | 396 | WP_070383282.1 | DUF3465 domain-containing protein | - |
| vm_RS21690 | 26468..26581 | + | 114 | WP_081337942.1 | acetyltransferase | - |
| vm_RS15275 | 26530..26811 | + | 282 | WP_081337943.1 | DUF1289 domain-containing protein | - |
| vm_RS15290 | 27569..28024 | + | 456 | WP_070382649.1 | hypothetical protein | - |
| vm_RS15295 | 28319..28501 | + | 183 | WP_000923327.1 | DUF645 family protein | - |
| vm_RS15300 | 28701..29087 | + | 387 | WP_070382650.1 | MmcQ/YjbR family DNA-binding protein | - |
| vm_RS15305 | 29826..30239 | + | 414 | WP_070382651.1 | hypothetical protein | - |
| vm_RS15310 | 30428..30685 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| vm_RS15315 | 30673..30975 | + | 303 | WP_000229322.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| vm_RS15320 | 31141..31671 | + | 531 | WP_070382652.1 | GNAT family N-acetyltransferase | - |
| vm_RS21575 | 32002..32070 | + | 69 | WP_155761238.1 | hypothetical protein | - |
| vm_RS15330 | 32216..32581 | + | 366 | WP_081338031.1 | hypothetical protein | - |
| vm_RS15335 | 32737..33303 | + | 567 | WP_070382654.1 | hypothetical protein | - |
| vm_RS21235 | 33399..33647 | + | 249 | WP_155761239.1 | DUF3709 domain-containing protein | - |
| vm_RS21695 | 33915..34211 | + | 297 | WP_070382655.1 | GNAT family N-acetyltransferase | - |
| vm_RS21700 | 34283..34408 | + | 126 | WP_070382656.1 | GNAT family acetyltransferase | - |
| vm_RS15350 | 34545..35060 | + | 516 | WP_070382657.1 | lipocalin family protein | - |
| vm_RS15355 | 35125..35706 | + | 582 | WP_070382658.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / ugd / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / lfgG / hlyA | 41..1270905 | 1270864 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11737.67 Da Isoelectric Point: 5.1972
>T64542 WP_000229322.1 NZ_CP016384:30673-30975 [Vibrio mimicus]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T64542 NZ_CP016384:30673-30975 [Vibrio mimicus]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAATTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAATTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT64542 WP_000861987.1 NZ_CP016384:30428-30685 [Vibrio mimicus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT64542 NZ_CP016384:30428-30685 [Vibrio mimicus]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCTTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCTTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0PYS1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SLM9 |