Detailed information of TA system TA064541

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 24017..24555
• Replicon: chromosome
• Accession: NZ_CP016384
• Organism: Vibrio mimicus strain SCCF01

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: vm_RS15250
• Protein ID: WP_070382644.1
• Coordinates: 24017..24316 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: vm_RS15255
• Protein ID: WP_070382645.1
• Coordinates: 24313..24555 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
vm_RS15220	19051..19803	+	753	WP_070382639.1	SDR family oxidoreductase	-
vm_RS15225	19968..20426	+	459	WP_070382640.1	hypothetical protein	-
vm_RS15230	20814..21218	+	405	WP_070382641.1	hypothetical protein	-
vm_RS15235	21401..21904	+	504	WP_001158944.1	DinB family protein	-
vm_RS15240	22060..22812	+	753	WP_070382642.1	SDR family oxidoreductase	-
vm_RS15245	22958..23902	+	945	WP_070382643.1	SIR2 family protein	-
vm_RS21185	23881..24009	+	129	WP_080532989.1	DUF3265 domain-containing protein	-
vm_RS15250	24017..24316	-	300	WP_070382644.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
vm_RS15255	24313..24555	-	243	WP_070382645.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
vm_RS15260	24765..25199	+	435	WP_070382646.1	GNAT family N-acetyltransferase	-
vm_RS15265	25353..25853	+	501	WP_070382647.1	DUF4365 domain-containing protein	-
vm_RS21200	25871..25960	+	90	WP_196770055.1	DUF3265 domain-containing protein	-
vm_RS15270	26006..26401	+	396	WP_070383282.1	DUF3465 domain-containing protein	-
vm_RS21690	26468..26581	+	114	WP_081337942.1	acetyltransferase	-
vm_RS15275	26530..26811	+	282	WP_081337943.1	DUF1289 domain-containing protein	-
vm_RS15290	27569..28024	+	456	WP_070382649.1	hypothetical protein	-
vm_RS15295	28319..28501	+	183	WP_000923327.1	DUF645 family protein	-
vm_RS15300	28701..29087	+	387	WP_070382650.1	MmcQ/YjbR family DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	cqsA / ugd / hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / lfgG / hlyA	41..1270905	1270864

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11555.27 Da
• Isoelectric Point: 9.9232

>T64541 WP_070382644.1 NZ_CP016384:c24316-24017 [Vibrio mimicus]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKLPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Nucleotide

• Length: 300 bp

>T64541 NZ_CP016384:c24316-24017 [Vibrio mimicus]
ATGAAACCATTTAATCTTACTGTCGCCGCTAAAGCCGATTTACGGGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATCGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAACTTCCCCAAGGGAGTCACGTCATCTTTTATCAACAAACCGGCAGCCAACAA
ATCCGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8980.84 Da
• Isoelectric Point: 4.1677

>AT64541 WP_070382645.1 NZ_CP016384:c24555-24313 [Vibrio mimicus]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDTDYDLDSFINELDSENIR

Nucleotide

• Length: 243 bp

>AT64541 NZ_CP016384:c24555-24313 [Vibrio mimicus]
ATGGCTAAAAACACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTGTTGAAGGAGAGCAAAGTGGTGACACTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA