Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 16426..16988 Replicon plasmid unnamed
Accession NZ_CP016375
Organism Elizabethkingia anophelis strain F3201

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BBD32_RS19485 Protein ID WP_185117104.1
Coordinates 16426..16746 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BBD32_RS19490 Protein ID WP_078396993.1
Coordinates 16740..16988 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBD32_RS19450 12301..13380 + 1080 WP_078396985.1 grasp-with-spasm system SPASM domain peptide maturase -
BBD32_RS19455 13490..14398 - 909 WP_078396986.1 lytic transglycosylase domain-containing protein -
BBD32_RS19915 14875..15018 - 144 WP_164504643.1 hypothetical protein -
BBD32_RS19465 15199..15468 - 270 WP_078396988.1 hypothetical protein -
BBD32_RS19470 15479..15766 - 288 WP_078396989.1 hypothetical protein -
BBD32_RS19475 15766..15993 - 228 WP_078396990.1 hypothetical protein -
BBD32_RS19480 16012..16371 - 360 WP_078396991.1 hypothetical protein -
BBD32_RS19485 16426..16746 - 321 WP_185117104.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BBD32_RS19490 16740..16988 - 249 WP_078396993.1 hypothetical protein Antitoxin
BBD32_RS19495 17179..17703 - 525 WP_078396994.1 hypothetical protein -
BBD32_RS19500 17802..18386 + 585 WP_078396995.1 outer membrane beta-barrel protein -
BBD32_RS19505 18483..19937 - 1455 WP_078396996.1 DUF3872 domain-containing protein -
BBD32_RS19510 19959..20531 - 573 WP_078396997.1 hypothetical protein -
BBD32_RS19515 20554..21222 - 669 WP_164504644.1 DUF4138 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..35268 35268


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12085.32 Da        Isoelectric Point: 10.0640

>T64534 WP_185117104.1 NZ_CP016375:c16746-16426 [Elizabethkingia anophelis]
MVIKRFDVFFIDLNPTVGSEINKIRPCVIISPDEMNNALNTVIIAPLTSTIKPYPMRVNCRVEGKKGQVALDHLRSVDKR
RLKAKMASLDKHTQEEIIDTLMKMFS

Download         Length: 321 bp

>T64534 NZ_CP016375:c16746-16426 [Elizabethkingia anophelis]
ATGGTAATTAAAAGATTTGATGTTTTCTTTATCGATCTAAATCCTACTGTAGGTAGTGAAATCAATAAGATCAGACCGTG
TGTGATAATTTCTCCGGACGAAATGAATAATGCTTTAAATACAGTAATTATAGCCCCTTTGACGTCTACAATAAAGCCAT
ATCCAATGAGAGTAAACTGCAGGGTTGAGGGTAAAAAGGGGCAGGTTGCTTTAGATCATTTGAGATCTGTGGATAAGAGA
AGATTGAAAGCAAAGATGGCCAGTTTGGATAAGCACACACAAGAAGAAATTATTGATACTCTCATGAAAATGTTTTCTTA
G

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9518.90 Da        Isoelectric Point: 4.4879

>AT64534 WP_078396993.1 NZ_CP016375:c16988-16740 [Elizabethkingia anophelis]
MKTKVRKIGNSFGIIIGKKLLEQAEVKEEVSLSIEDSKIIIEAVKSNPRAGWEEMLLKAKSLEDTEFLEDFENEFDKTEW
TW

Download         Length: 249 bp

>AT64534 NZ_CP016375:c16988-16740 [Elizabethkingia anophelis]
ATGAAAACAAAAGTTAGAAAAATAGGTAACTCCTTCGGAATTATTATTGGAAAGAAGCTGTTAGAACAAGCCGAAGTTAA
AGAAGAAGTTTCTTTATCCATCGAAGATTCTAAAATAATAATTGAAGCGGTTAAGAGTAATCCCCGCGCAGGCTGGGAAG
AAATGTTGCTAAAAGCTAAATCTTTAGAAGATACAGAGTTTTTAGAAGATTTTGAGAATGAGTTTGACAAAACAGAGTGG
ACATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References