Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3923563..3924398 Replicon chromosome
Accession NZ_CP016358
Organism Escherichia coli strain K-15KW01

Toxin (Protein)


Gene name yeeV Uniprot ID Q83W73
Locus tag BA058_RS19135 Protein ID WP_000854700.1
Coordinates 3924021..3924398 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag BA058_RS19130 Protein ID WP_001278232.1
Coordinates 3923563..3923931 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA058_RS19105 3921223..3922041 + 819 WP_001234709.1 DUF945 domain-containing protein -
BA058_RS19110 3922133..3922618 + 486 WP_000213723.1 antirestriction protein -
BA058_RS19115 3922634..3923110 + 477 WP_001186199.1 RadC family protein -
BA058_RS19120 3923179..3923400 + 222 WP_000692353.1 DUF987 domain-containing protein -
BA058_RS19130 3923563..3923931 + 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
BA058_RS19135 3924021..3924398 + 378 WP_000854700.1 TA system toxin CbtA family protein Toxin
BA058_RS19140 3924395..3924883 + 489 WP_000761726.1 hypothetical protein -
BA058_RS19145 3924895..3925092 + 198 WP_000839247.1 DUF957 domain-containing protein -
BA058_RS19150 3925177..3926031 + 855 WP_024174313.1 DUF4942 domain-containing protein -
BA058_RS19155 3926294..3927040 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
BA058_RS19160 3927055..3928596 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14276.28 Da        Isoelectric Point: 7.8046

>T64526 WP_000854700.1 NZ_CP016358:3924021-3924398 [Escherichia coli]
MKTLPDTHVREASRCLSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SPCTRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T64526 NZ_CP016358:3924021-3924398 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCTGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTGCGTACCGACCAGCCGGGATTC
AGCCCCTGTACCCGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT64526 WP_001278232.1 NZ_CP016358:3923563-3923931 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT64526 NZ_CP016358:3923563-3923931 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A1I2

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References