Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3408784..3409619 Replicon chromosome
Accession NZ_CP016358
Organism Escherichia coli strain K-15KW01

Toxin (Protein)


Gene name yeeV Uniprot ID Q1R2L4
Locus tag BA058_RS16590 Protein ID WP_001094426.1
Coordinates 3409242..3409619 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q1R2L5
Locus tag BA058_RS16585 Protein ID WP_001285575.1
Coordinates 3408784..3409152 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA058_RS16550 3404676..3405356 + 681 WP_001282919.1 WYL domain-containing protein -
BA058_RS16555 3405504..3406181 + 678 WP_001097301.1 hypothetical protein -
BA058_RS16560 3406187..3406420 + 234 WP_001278290.1 DUF905 family protein -
BA058_RS16565 3406510..3407328 + 819 WP_065377599.1 DUF945 domain-containing protein -
BA058_RS16570 3407420..3407905 + 486 WP_000214415.1 antirestriction protein -
BA058_RS16575 3407920..3408396 + 477 WP_001298074.1 RadC family protein -
BA058_RS16580 3408483..3408704 + 222 WP_000692350.1 DUF987 domain-containing protein -
BA058_RS16585 3408784..3409152 + 369 WP_001285575.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BA058_RS16590 3409242..3409619 + 378 WP_001094426.1 TA system toxin CbtA family protein Toxin
BA058_RS16595 3409616..3410104 + 489 WP_000761683.1 hypothetical protein -
BA058_RS16600 3410116..3410313 + 198 WP_000839272.1 DUF957 domain-containing protein -
BA058_RS28260 3410392..3410550 + 159 WP_001467148.1 hypothetical protein -
BA058_RS16605 3411499..3413535 + 2037 WP_000417001.1 hypothetical protein -
BA058_RS16610 3413934..3414113 - 180 WP_001298063.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14072.99 Da        Isoelectric Point: 7.3523

>T64517 WP_001094426.1 NZ_CP016358:3409242-3409619 [Escherichia coli]
MNTLPDTHIREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T64517 NZ_CP016358:3409242-3409619 [Escherichia coli]
ATGAACACATTACCCGATACACACATACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13709.52 Da        Isoelectric Point: 6.6258

>AT64517 WP_001285575.1 NZ_CP016358:3408784-3409152 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT64517 NZ_CP016358:3408784-3409152 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454ABD6

Antitoxin

Source ID Structure
AlphaFold DB A0A454ABF5

References