Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 2989993..2990981 Replicon chromosome
Accession NZ_CP016358
Organism Escherichia coli strain K-15KW01

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag BA058_RS14475 Protein ID WP_014640052.1
Coordinates 2990595..2990981 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag BA058_RS14470 Protein ID WP_021538830.1
Coordinates 2989993..2990565 (+) Length 191 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA058_RS14445 2986153..2986521 + 369 WP_000002899.1 diacylglycerol kinase -
BA058_RS14450 2986631..2987239 + 609 WP_000646078.1 transcriptional repressor LexA -
BA058_RS14455 2987312..2988637 + 1326 WP_001298291.1 MATE family efflux transporter DinF -
BA058_RS14460 2988753..2988962 + 210 WP_001296638.1 CsbD family protein -
BA058_RS14465 2989004..2989519 - 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
BA058_RS14470 2989993..2990565 + 573 WP_021538830.1 SocA family protein Antitoxin
BA058_RS14475 2990595..2990981 + 387 WP_014640052.1 hypothetical protein Toxin
BA058_RS28240 2991021..2991194 + 174 WP_021538831.1 hypothetical protein -
BA058_RS14480 2991242..2991523 - 282 WP_001093916.1 pyocin activator PrtN family protein -
BA058_RS14485 2991560..2992132 - 573 WP_023145273.1 3'-5' exoribonuclease -
BA058_RS14490 2992132..2992872 - 741 WP_023145274.1 hypothetical protein -
BA058_RS14500 2992876..2993163 - 288 WP_000212745.1 hypothetical protein -
BA058_RS14505 2993165..2993950 - 786 WP_021529121.1 ead/Ea22-like family protein -
BA058_RS14510 2993937..2994185 - 249 WP_000476209.1 hypothetical protein -
BA058_RS14515 2994178..2994381 - 204 WP_000111289.1 hypothetical protein -
BA058_RS14520 2994378..2994740 - 363 WP_001242718.1 phage protein -
BA058_RS14525 2994731..2995267 - 537 WP_000008177.1 5'-deoxynucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2986631..3035840 49209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-137)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T64515 WP_014640052.1 NZ_CP016358:2990595-2990981 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T64515 NZ_CP016358:2990595-2990981 [Escherichia coli]
GTGCTTGCCCCAACAGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21987.31 Da        Isoelectric Point: 5.6404

>AT64515 WP_021538830.1 NZ_CP016358:2989993-2990565 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHDPGYSRKPIDLKEMLI
SEGKSEDEANHIIGKMEESQKLKEFSLQLS

Download         Length: 573 bp

>AT64515 NZ_CP016358:2989993-2990565 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAACT
GATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAGTT
GAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATTTGATCTCGCAAACATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCCGGCTATTCCCGTAAGCCTATAGATCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCATATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References