Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 228151..229873 Replicon chromosome
Accession NZ_CP016351
Organism Vibrio natriegens strain CCUG 16374

Toxin (Protein)


Gene name mosT Uniprot ID A0A1B1E9C2
Locus tag BA894_RS01010 Protein ID WP_065296148.1
Coordinates 228935..229873 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A1B1E8Q3
Locus tag BA894_RS01005 Protein ID WP_065296147.1
Coordinates 228151..228942 (+) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BA894_RS00985 223347..225446 + 2100 WP_065296144.1 YjbH domain-containing protein -
BA894_RS00990 225681..225905 - 225 WP_001147121.1 hypothetical protein -
BA894_RS00995 225906..226190 - 285 WP_065296145.1 helix-turn-helix domain-containing protein -
BA894_RS01000 226187..227881 - 1695 WP_065296146.1 DUF927 domain-containing protein -
BA894_RS01005 228151..228942 + 792 WP_065296147.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
BA894_RS01010 228935..229873 + 939 WP_065296148.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
BA894_RS01015 229912..232041 + 2130 WP_065296149.1 site-specific DNA-methyltransferase -
BA894_RS01020 232045..234645 + 2601 WP_065296150.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 222314..236409 14095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(13-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35464.63 Da        Isoelectric Point: 4.8550

>T64493 WP_065296148.1 NZ_CP016351:228935-229873 [Vibrio natriegens]
MDRESPYYKQVSLLIRMLPVVATEPSFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRNEALENVKAALQRITDLINKE
PENRAVLQDHRLDELRIVVKSPNATIKIEVSPVARGTLHKPDSLAVQESVEEEFGYAEVPVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLAEEGISRDIFVGFITYVLSHPRPINEVMAPNWQSLDDKFQAEFDGMTFEPVELKDLISTRPAMVAALQA
HFTEKDRSFLLSFKQGNPDWSLFDYPDAAELPAIRWKLQNIAKLAKNQEKHVEQLTKLESVLDEWLKQANTN

Download         Length: 939 bp

>T64493 NZ_CP016351:228935-229873 [Vibrio natriegens]
ATGGATAGAGAGAGCCCTTATTACAAGCAGGTTTCACTGCTGATTAGAATGTTACCAGTGGTTGCAACAGAACCTTCATT
TGCACTCAAAGGTGGTACAGCTATCAACTTATTTGTGAGAGATTTTCCACGCTTGTCTGTGGATATTGATCTTGCTTATC
TTCCTCTTGAGCCGAGAAATGAAGCTCTAGAAAATGTAAAAGCAGCATTGCAACGTATAACCGATTTAATCAACAAAGAA
CCTGAGAACCGAGCTGTATTGCAGGACCATAGGTTAGATGAATTGCGTATTGTTGTTAAAAGTCCTAATGCAACAATTAA
AATAGAAGTCTCTCCGGTAGCAAGAGGTACGTTGCATAAACCTGATAGCTTAGCTGTCCAAGAATCAGTCGAAGAAGAGT
TTGGTTATGCAGAGGTTCCTGTAGTTAGTCTGCCCGATCTTTATGGCGGAAAACTATGTGCTGCCATGGATCGCCAGCAC
CCTCGCGACCTGTTTGATGTTCGTATGCTGCTTGCAGAGGAAGGTATTTCACGAGATATCTTTGTTGGATTCATTACTTA
CGTACTAAGCCACCCAAGACCTATCAATGAGGTTATGGCTCCTAACTGGCAATCTCTTGATGATAAGTTTCAAGCTGAGT
TCGATGGCATGACCTTTGAACCCGTTGAGTTAAAAGACTTAATTTCTACAAGGCCTGCGATGGTCGCTGCACTACAAGCC
CACTTCACAGAAAAAGATCGCTCATTTTTGTTGTCATTCAAACAAGGGAATCCTGATTGGTCACTGTTTGACTACCCAGA
TGCAGCTGAACTGCCAGCTATACGCTGGAAGCTTCAAAACATAGCTAAGTTAGCTAAGAATCAAGAAAAACATGTAGAGC
AGCTAACTAAGTTAGAGTCTGTACTTGATGAGTGGCTTAAGCAAGCTAATACCAATTAA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 29876.01 Da        Isoelectric Point: 9.6656

>AT64493 WP_065296147.1 NZ_CP016351:228151-228942 [Vibrio natriegens]
MSSKINWLVANAYPGALVLQQWLTENGISYSLAQKYAQSGWLRKLSSGVYYRPGAKDDVKPGWVDALQAMDTQLHHRVHL
AGLSSLTHQGLSHYLQLSKEQVWIGVKNKQSLPKWFREFPNQNWFYCGNHKLEAVSDKDLKVITVKGKELKASCPELAAY
EVVDAIGKQISFEHAAELFQGLVNLSPRKVQSLLERSSSVQTNRVFLFLSHYHGHQWTQRIDETKIALGSGKRQVVEQGR
FDERYQITVPEILSVKKEEANNG

Download         Length: 792 bp

>AT64493 NZ_CP016351:228151-228942 [Vibrio natriegens]
ATGTCATCCAAGATAAACTGGTTGGTAGCCAATGCATATCCTGGAGCCCTTGTGCTACAGCAATGGCTGACTGAGAACGG
AATTAGCTATTCCTTAGCTCAAAAATATGCGCAGAGTGGTTGGCTTAGGAAGCTATCTTCAGGCGTTTATTATCGGCCAG
GCGCAAAAGATGATGTTAAGCCAGGCTGGGTGGATGCTCTACAAGCGATGGACACACAGTTGCACCATCGTGTTCATCTG
GCTGGGTTAAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTACAGCTAAGTAAAGAACAAGTTTGGATAGGGGTGAA
GAACAAACAATCATTACCTAAGTGGTTTCGTGAATTTCCCAATCAAAATTGGTTTTATTGTGGTAACCATAAGCTTGAAG
CTGTCTCTGACAAGGACCTAAAAGTGATTACGGTTAAAGGAAAAGAGCTAAAAGCTAGTTGCCCAGAGCTTGCTGCTTAC
GAAGTTGTTGATGCAATCGGGAAGCAAATTTCGTTTGAGCATGCAGCAGAGCTTTTTCAAGGCCTTGTAAACCTGAGCCC
TAGAAAGGTGCAATCTCTTCTTGAACGTAGTAGCTCGGTTCAAACCAATAGAGTGTTTTTGTTTTTGAGTCATTATCATG
GGCATCAGTGGACTCAGCGCATTGATGAAACAAAGATCGCATTAGGTTCAGGAAAGCGTCAGGTGGTAGAGCAAGGGCGA
TTTGATGAGCGTTACCAAATCACTGTGCCAGAGATATTAAGTGTAAAAAAAGAAGAAGCAAACAATGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1E9C2

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1E8Q3

References