Detailed information of TA system TA064492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 2126058..2126623
• Replicon: chromosome
• Accession: NZ_CP016349
• Organism: Vibrio natriegens strain CCUG 16373

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BA893_RS09620
• Protein ID: WP_065299857.1
• Coordinates: 2126058..2126345 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: BA893_RS09625
• Protein ID: WP_000086647.1
• Coordinates: 2126342..2126623 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BA893_RS09605	2123849..2124184	-	336	WP_065299855.1	5-carboxymethyl-2-hydroxymuconate isomerase	-
BA893_RS09610	2124319..2124726	-	408	WP_014232128.1	OsmC family protein	-
BA893_RS09615	2124890..2125357	-	468	WP_065299856.1	ASCH domain-containing protein	-
BA893_RS26120	2125926..2126048	-	123	Protein_1874	DUF3265 domain-containing protein	-
BA893_RS09620	2126058..2126345	-	288	WP_065299857.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BA893_RS09625	2126342..2126623	-	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BA893_RS09630	2126792..2128003	-	1212	Protein_1877	DUF3644 domain-containing protein	-
BA893_RS25820	2128025..2128138	-	114	WP_155760026.1	DUF3265 domain-containing protein	-
BA893_RS09635	2128156..2128398	-	243	WP_065299858.1	hypothetical protein	-
BA893_RS09640	2128605..2129051	-	447	WP_029817141.1	GNAT family N-acetyltransferase	-
BA893_RS09645	2129186..2129788	-	603	WP_065299859.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	2125924..2140410	14486

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11015.73 Da
• Isoelectric Point: 5.6096

>T64492 WP_065299857.1 NZ_CP016349:c2126345-2126058 [Vibrio natriegens]
MKVVWSPLALQKLGDAAEFISLDNPLAAERWVNEVFDKTELLGSMPEMGRFVPELPHTNYREIIFGHYRIIYSLSHEIRI
LTVRNCRQILSESDV

Nucleotide

• Length: 288 bp

>T64492 NZ_CP016349:c2126345-2126058 [Vibrio natriegens]
ATGAAAGTAGTCTGGTCTCCATTGGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAATCCACTTGC
GGCAGAGAGGTGGGTAAACGAAGTTTTTGATAAAACTGAACTCCTGGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AACTGCCCCATACGAACTATCGCGAAATCATCTTTGGCCACTACCGTATTATCTACAGTTTAAGCCACGAAATTCGCATA
CTAACAGTTCGTAACTGTCGTCAAATTTTATCTGAAAGTGACGTGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT64492 WP_000086647.1 NZ_CP016349:c2126623-2126342 [Vibrio natriegens]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT64492 NZ_CP016349:c2126623-2126342 [Vibrio natriegens]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTGTCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACGCAACGTGGCAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CTATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGCACAGCAGAAGCTCAGTTAGCTTCTGGTCTCGGTGTTTCCAAT
GATGATGCGCGTGCTCAAGTTCTTGGGCGCATTAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0