Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3969823..3970486 Replicon chromosome
Accession NZ_CP016337
Organism Kosakonia sacchari strain BO-1

Toxin (Protein)


Gene name cptA Uniprot ID A0A1G4Y1E1
Locus tag BBB57_RS18910 Protein ID WP_017457617.1
Coordinates 3970070..3970486 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1G4Y1L0
Locus tag BBB57_RS18905 Protein ID WP_017457616.1
Coordinates 3969823..3970089 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBB57_RS18885 3965353..3966786 - 1434 WP_065370110.1 6-phospho-beta-glucosidase -
BBB57_RS18890 3966903..3967631 - 729 WP_025263844.1 MurR/RpiR family transcriptional regulator -
BBB57_RS18895 3967871..3968530 + 660 WP_017457614.1 hemolysin III family protein -
BBB57_RS18900 3968593..3969576 - 984 WP_065370111.1 tRNA-modifying protein YgfZ -
BBB57_RS18905 3969823..3970089 + 267 WP_017457616.1 FAD assembly factor SdhE Antitoxin
BBB57_RS18910 3970070..3970486 + 417 WP_017457617.1 protein YgfX Toxin
BBB57_RS18915 3970500..3971021 - 522 WP_020455133.1 flavodoxin FldB -
BBB57_RS18920 3971121..3972017 + 897 WP_065370112.1 site-specific tyrosine recombinase XerD -
BBB57_RS18925 3972042..3972755 + 714 WP_017457620.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BBB57_RS18930 3972761..3974494 + 1734 WP_065370113.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16372.32 Da        Isoelectric Point: 11.0079

>T64463 WP_017457617.1 NZ_CP016337:3970070-3970486 [Kosakonia sacchari]
VVLWQSDLRVSWRAQWISLLLHGLVAAFILFMPWPLSYTPLWLLLLSLVVFDCVRSQRRINACHGEIKLLMDSRLRWQGV
EWDIVGTPWMIRGGMMLRLRRAEDGRRQHLWLAADSMDSQEWRDLRRMIIQNPAQGLH

Download         Length: 417 bp

>T64463 NZ_CP016337:3970070-3970486 [Kosakonia sacchari]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCACAATGGATTTCGTTATTACTGCACGGATTGGTGGCGGC
CTTCATTCTTTTTATGCCATGGCCGTTGAGCTATACGCCGCTGTGGCTTTTGCTGCTGTCGCTGGTGGTTTTCGACTGCG
TACGCAGCCAGCGGCGGATTAACGCCTGCCACGGCGAAATCAAACTGCTCATGGATTCCCGCCTGCGCTGGCAAGGTGTG
GAGTGGGATATTGTCGGTACACCCTGGATGATTCGCGGCGGCATGATGTTGCGTTTACGCCGTGCGGAAGATGGGCGGCG
CCAGCATTTATGGCTGGCGGCAGACAGCATGGATTCGCAGGAGTGGCGCGATCTACGCCGGATGATTATCCAAAATCCGG
CGCAGGGGCTGCATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10521.95 Da        Isoelectric Point: 6.0701

>AT64463 WP_017457616.1 NZ_CP016337:3969823-3970089 [Kosakonia sacchari]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDHDKQVFVRLLESDDPDLFNWLMNHGKPQDAELQRMVQLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT64463 NZ_CP016337:3969823-3970089 [Kosakonia sacchari]
ATGGATATTAATAATAAAGCCCGTATCCATTGGGCCTGTCGCCGCGGAATGCGCGAACTCGATATCTCCATCATGCCTTT
TTTTGAACATGAGTACGACTCGCTCAGTGACCACGACAAACAGGTGTTTGTGCGTCTGCTGGAGAGTGATGATCCGGATT
TATTCAACTGGTTGATGAATCATGGCAAACCCCAGGACGCGGAGTTGCAGCGAATGGTGCAGTTAATTCAGACACGGAAT
CGGGATCGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G4Y1E1

Antitoxin

Source ID Structure
AlphaFold DB A0A1G4Y1L0

References