Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3688450..3688966 Replicon chromosome
Accession NZ_CP016337
Organism Kosakonia sacchari strain BO-1

Toxin (Protein)


Gene name relE Uniprot ID A0A1G4YUH3
Locus tag BBB57_RS17545 Protein ID WP_017459098.1
Coordinates 3688682..3688966 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1G4YUC9
Locus tag BBB57_RS17540 Protein ID WP_017459099.1
Coordinates 3688450..3688692 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBB57_RS17525 3684554..3686464 + 1911 WP_065369951.1 BglG family transcription antiterminator -
BBB57_RS17530 3686499..3687332 - 834 WP_065369952.1 oxidoreductase -
BBB57_RS17535 3687437..3688357 + 921 WP_065369953.1 AraC family transcriptional regulator -
BBB57_RS17540 3688450..3688692 + 243 WP_017459099.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BBB57_RS17545 3688682..3688966 + 285 WP_017459098.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BBB57_RS17550 3688972..3689436 - 465 WP_065369954.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
BBB57_RS17555 3689624..3691759 - 2136 WP_065369955.1 anaerobic ribonucleoside-triphosphate reductase -
BBB57_RS17560 3692144..3693799 - 1656 WP_017459095.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-75)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11047.02 Da        Isoelectric Point: 10.7335

>T64462 WP_017459098.1 NZ_CP016337:3688682-3688966 [Kosakonia sacchari]
MNYELVFDPRAYKEWKKLGATVKTQFKKKLAAVLVQPRIEKTRLHQFPDCYKIKLRSSGYRLVYQVRDHVVTVFVVSIGK
REKAAAYQDASKRL

Download         Length: 285 bp

>T64462 NZ_CP016337:3688682-3688966 [Kosakonia sacchari]
ATGAATTATGAGCTGGTGTTTGATCCCCGCGCATACAAAGAATGGAAAAAACTCGGTGCCACGGTAAAAACACAGTTCAA
AAAGAAACTGGCGGCTGTGCTGGTTCAACCCAGAATTGAAAAGACCCGACTGCATCAATTTCCGGATTGCTACAAGATCA
AATTGCGATCATCAGGCTACCGGTTGGTCTATCAGGTCAGAGACCATGTGGTGACGGTATTCGTTGTGTCTATCGGTAAA
CGCGAAAAAGCCGCCGCTTATCAGGATGCCAGCAAGCGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9176.65 Da        Isoelectric Point: 4.8409

>AT64462 WP_017459099.1 NZ_CP016337:3688450-3688692 [Kosakonia sacchari]
MATLNVRLDDKLKEEAWRVLEKLNITPTEAVRLLFQYVAENGRMPIKTVTVSEDESALLEIVRERLANPQKGIKVNLDEL

Download         Length: 243 bp

>AT64462 NZ_CP016337:3688450-3688692 [Kosakonia sacchari]
ATGGCGACGCTAAATGTTCGACTGGATGACAAACTCAAAGAAGAGGCCTGGCGCGTGCTGGAAAAACTCAATATCACCCC
AACCGAAGCCGTTCGCTTACTGTTCCAATATGTCGCTGAAAACGGGCGTATGCCGATCAAAACAGTGACGGTGAGCGAGG
ACGAATCGGCGTTGCTGGAGATTGTCCGGGAGCGCCTGGCGAACCCGCAAAAAGGCATCAAGGTTAATCTGGATGAATTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G4YUH3

Antitoxin

Source ID Structure
AlphaFold DB A0A1G4YUC9

References