Detailed information of TA system TA064448

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1191828..1192357
• Replicon: chromosome
• Accession: NZ_CP016335
• Organism: Corynebacterium glutamicum strain ATCC 13869

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BBD29_RS15520
• Protein ID: WP_075348157.1
• Coordinates: 1192058..1192357 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1B4WJV4
• Locus tag: BBD29_RS05580
• Protein ID: WP_060564305.1
• Coordinates: 1191828..1192061 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBD29_RS05560	1187873..1189096	-	1224	WP_004568082.1	esterase family protein	-
BBD29_RS05565	1189292..1190377	+	1086	WP_004568081.1	redox-regulated ATPase YchF	-
BBD29_RS05570	1190542..1190787	+	246	WP_060564304.1	hypothetical protein	-
BBD29_RS05575	1191121..1191561	+	441	WP_038583357.1	YtoQ family protein	-
BBD29_RS05580	1191828..1192061	+	234	WP_060564305.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
BBD29_RS15520	1192058..1192357	+	300	WP_075348157.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BBD29_RS05585	1192396..1192662	+	267	WP_087061857.1	helix-turn-helix transcriptional regulator	-
BBD29_RS05590	1192880..1193353	-	474	WP_081302985.1	SAP domain-containing protein	-
BBD29_RS05595	1193519..1194031	-	513	WP_146144404.1	hypothetical protein	-
BBD29_RS05600	1194251..1194709	+	459	WP_060564309.1	NUDIX domain-containing protein	-
BBD29_RS05605	1194873..1195256	+	384	WP_060564310.1	class I SAM-dependent methyltransferase	-
BBD29_RS05610	1195406..1196431	-	1026	WP_060564311.1	hypothetical protein	-
BBD29_RS05615	1196436..1197014	-	579	WP_060564312.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1191121..1201652	10531

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-74)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11529.07 Da
• Isoelectric Point: 10.6281

>T64448 WP_075348157.1 NZ_CP016335:1192058-1192357 [Corynebacterium glutamicum]
VSRYLLTPAAQHDLSLIWDFTESRWGISQAKKYIREIQSAVEYVAQDANRGRSREEIRLGYKSTAVGSHVIFYVQRTSHW
KAMKQPVWRPTSARQFVTS

Nucleotide

• Length: 300 bp

>T64448 NZ_CP016335:1192058-1192357 [Corynebacterium glutamicum]
GTGAGCAGGTACCTTCTTACACCGGCTGCACAGCATGATCTCTCCTTGATTTGGGATTTCACCGAGAGTCGTTGGGGTAT
AAGCCAAGCAAAGAAGTATATCCGTGAGATTCAATCAGCAGTGGAATATGTGGCACAAGATGCGAACCGTGGCCGTAGTC
GTGAGGAAATTCGCTTAGGTTATAAAAGCACTGCGGTAGGCAGCCATGTCATATTTTATGTCCAGCGCACGAGCCATTGG
AAGGCAATGAAACAGCCTGTCTGGAGACCGACATCGGCCAGGCAGTTCGTGACCTCATAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8475.39 Da
• Isoelectric Point: 4.1948

>AT64448 WP_060564305.1 NZ_CP016335:1191828-1192061 [Corynebacterium glutamicum]
MAMNTSISLDDHFASFLSEQVESGRYQTASEVIRAGLRLLEEREARLTALRAALVNGEMSGEAEEFDFDAFIASKSS

Nucleotide

• Length: 234 bp

>AT64448 NZ_CP016335:1191828-1192061 [Corynebacterium glutamicum]
ATGGCCATGAATACTTCCATCAGTCTTGATGATCATTTCGCTTCGTTCCTCAGTGAGCAGGTTGAATCCGGTCGGTACCA
GACAGCGAGTGAGGTCATCCGTGCAGGTCTGCGCTTGTTGGAGGAGCGGGAAGCTCGTCTAACTGCTTTACGTGCGGCGC
TTGTAAATGGAGAGATGAGTGGTGAGGCAGAAGAATTTGATTTTGATGCCTTTATCGCATCGAAAAGCTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B4WJV4